Title |
High resolution SPECT imaging for visualization of intratumoral heterogeneity using a SPECT/CT scanner dedicated for small animal imaging
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Published in |
Annals of Nuclear Medicine, October 2011
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DOI | 10.1007/s12149-011-0542-7 |
Pubmed ID | |
Authors |
Izumi O. Umeda, Kotaro Tani, Keisuke Tsuda, Masamitsu Kobayashi, Mayumi Ogata, Sadaaki Kimura, Mitsuyoshi Yoshimoto, Shuji Kojima, Kunikazu Moribe, Keiji Yamamoto, Noriyuki Moriyama, Hirofumi Fujii |
Abstract |
Tumor interiors are never homogeneous and in vivo visualization of intratumoral heterogeneity would be an innovation that contributes to improved cancer therapy. But, conventional nuclear medicine tests have failed to visualize heterogeneity in vivo because of limited spatial resolution. Recently developed single photon emission computed tomographic (SPECT) scanners dedicated for small animal imaging are of interest due to their excellent spatial resolution of <1 mm, but few studies have focused on the evaluation of intratumoral heterogeneity. We investigated the optimal conditions related to high resolution imaging of heterogeneous tumor interiors using a small animal SPECT scanner. |
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