| Title |
Acute exercise modulates cigarette cravings and brain activation in response to smoking-related images: an fMRI study
|
|---|---|
| Published in |
Psychopharmacology, November 2008
|
| DOI | 10.1007/s00213-008-1405-3 |
| Pubmed ID | |
| Authors |
Kate Janse Van Rensburg, Adrian Taylor, Tim Hodgson, Abdelmalek Benattayallah |
| Abstract |
Substances of misuse (such as nicotine) are associated with increases in activation within the mesocorticolimbic brain system, a system thought to mediate the rewarding effects of drugs of abuse. Pharmacological treatments have been designed to reduce cigarette cravings during temporary abstinence. Exercise has been found to be an effective tool for controlling cigarette cravings. The objective of this study is to assess the effect of exercise on regional brain activation in response to smoking-related images during temporary nicotine abstinence. In a randomized crossover design, regular smokers (n = 10) undertook an exercise (10 min moderate-intensity stationary cycling) and control (passive seating for same duration) session, following 15 h of nicotine abstinence. Following treatments, participants entered a functional Magnetic Resonance Imaging (fMRI) scanner. Subjects viewed a random series of smoking and neutral images for 3 s, with an average inter-stimulus-interval (ISI) of 10 s. Self-reported cravings were assessed at baseline, mid-, and post-treatments. A significant interaction effect (time by group) was found, with self-reported cravings lower during and following exercise. During control scanning, significant activation was recorded in areas associated with reward (caudate nucleus), motivation (orbitofrontal cortex) and visuo-spatial attention (parietal lobe, parahippocampal, and fusiform gyrus). Post-exercise scanning showed hypo-activation in these areas with a concomitant shift of activation towards areas identified in the 'brain default mode' (Broadmanns Area 10). The study confirms previous evidence that a single session of exercise can reduce cigarette cravings, and for the first time provides evidence of a shift in regional activation in response to smoking cues. |
Mendeley readers
The data shown below were compiled from readership statistics for 170 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 5 | 3% |
| United Kingdom | 3 | 2% |
| Denmark | 2 | 1% |
| Germany | 1 | <1% |
| Taiwan | 1 | <1% |
| Japan | 1 | <1% |
| Spain | 1 | <1% |
| Unknown | 156 | 92% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 40 | 24% |
| Student > Master | 29 | 17% |
| Researcher | 23 | 14% |
| Professor > Associate Professor | 13 | 8% |
| Student > Doctoral Student | 12 | 7% |
| Other | 29 | 17% |
| Unknown | 24 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 48 | 28% |
| Medicine and Dentistry | 23 | 14% |
| Neuroscience | 15 | 9% |
| Agricultural and Biological Sciences | 13 | 8% |
| Sports and Recreations | 10 | 6% |
| Other | 29 | 17% |
| Unknown | 32 | 19% |
Attention Score in Context
This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 June 2009.
All research outputs
#3,249,865
of 22,655,397 outputs
Outputs from Psychopharmacology
#826
of 5,328 outputs
Outputs of similar age
#15,969
of 165,788 outputs
Outputs of similar age from Psychopharmacology
#6
of 39 outputs
Altmetric has tracked 22,655,397 research outputs across all sources so far. Compared to these this one has done well and is in the 84th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,328 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.6. This one has done well, scoring higher than 82% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 165,788 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 88% of its contemporaries.
We're also able to compare this research output to 39 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 82% of its contemporaries.