| Title |
miR-449b rs10061133 and miR-4293 rs12220909 polymorphisms are associated with decreased esophageal squamous cell carcinoma in a Chinese population
|
|---|---|
| Published in |
Tumor Biology, June 2015
|
| DOI | 10.1007/s13277-015-3422-2 |
| Pubmed ID | |
| Authors |
Ping Zhang, Jianguo Wang, Ting Lu, Xiaofeng Wang, Yabiao Zheng, Shicheng Guo, Yajun Yang, Mengyun Wang, Vijay Kumar Kolluri, Lixin Qiu, Fangyuan Shen, Lixia Fan, Jin Li, Yanong Wang, Qingyi Wei, Li Jin, Jiucun Wang, Minghua Wang |
| Abstract |
Esophageal cancer is one of the most aggressive cancers in the world, 70 % of which are from China and esophageal squamous cell carcinoma (ESCC) is the major histopathological form (>90 %). The single nucleotide polymorphisms (SNPs) in mature sequence of microRNA (miRNA) (mmSNPs) could cause the alteration of microRNA expression and contribute to the susceptibility of cancers. To evaluate the association between mmSNPs and ESCC, a case-control study including 773 patients with ESCC and 882 gender- and age-matched controls was carried out to investigate the association of five mmSNPs (miR-449b rs10061133, miR-4293 rs12220909, miR-608 rs4919510, miR-627 rs2620381, and miR-646 rs6513497) with ESCC susceptibility. As a result, two SNPs, miR-449b rs10061133 and miR-4293 rs12220909, were associated with decreased ESCC risk. For miR-449b rs10061133 A>G, individuals carrying GG genotype had an odds ratio (OR) of 0.77 (95 % confidence interval (95 % CI) 0.62-0.97) compared with individuals with AA genotype. In the recessive model, the GG genotype also showed a protective effect on ESCC (OR = 0.78, 95 % CI 0.63-0.97). For miR-4293 rs12220909 G>C, the heterozygous genotype GC was associated with a decreased ESCC risk (OR = 0.77, 95 % CI 0.61-0.97) compared with GG genotype. The C allele conferred 23 % decrease in ESCC risk compared with the G allele in the allelic model (95 % CI 0.63-0.93). In the dominant model, the GC/CC genotypes decreased the risk of ESCC (adjusted OR = 0.77, 95 % CI 0.61-0.96). This study provides the first evidence that miR-449b rs10061133 and miR-4293 rs12220909 are associated with ESCC risk in Chinese population. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 18 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Brazil | 1 | 6% |
| Unknown | 17 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 4 | 22% |
| Researcher | 4 | 22% |
| Student > Master | 3 | 17% |
| Student > Bachelor | 1 | 6% |
| Professor | 1 | 6% |
| Other | 3 | 17% |
| Unknown | 2 | 11% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 5 | 28% |
| Biochemistry, Genetics and Molecular Biology | 5 | 28% |
| Medicine and Dentistry | 2 | 11% |
| Economics, Econometrics and Finance | 2 | 11% |
| Unspecified | 1 | 6% |
| Other | 0 | 0% |
| Unknown | 3 | 17% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 June 2015.
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#20,278,422
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Outputs from Tumor Biology
#1,834
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#222,515
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Outputs of similar age from Tumor Biology
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