Title |
Weaponization of a Hormone: Convergent Recruitment of Hyperglycemic Hormone into the Venom of Arthropod Predators
|
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Published in |
Folding & Design, June 2015
|
DOI | 10.1016/j.str.2015.05.003 |
Pubmed ID | |
Authors |
Eivind A.B. Undheim, Lena L. Grimm, Chek-Fong Low, David Morgenstern, Volker Herzig, Pamela Zobel-Thropp, Sandy Steffany Pineda, Rosaline Habib, Slawomir Dziemborowicz, Bryan G. Fry, Graham M. Nicholson, Greta J. Binford, Mehdi Mobli, Glenn F. King |
Abstract |
Arthropod venoms consist primarily of peptide toxins that are injected into their prey with devastating consequences. Venom proteins are thought to be recruited from endogenous body proteins and mutated to yield neofunctionalized toxins with remarkable affinity for specific subtypes of ion channels and receptors. However, the evolutionary history of venom peptides remains poorly understood. Here we show that a neuropeptide hormone has been convergently recruited into the venom of spiders and centipedes and evolved into a highly stable toxin through divergent modification of the ancestral gene. High-resolution structures of representative hormone-derived toxins revealed they possess a unique structure and disulfide framework and that the key structural adaptation in weaponization of the ancestral hormone was loss of a C-terminal α helix, an adaptation that occurred independently in spiders and centipedes. Our results raise a new paradigm for toxin evolution and highlight the value of structural information in providing insight into protein evolution. |
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Scientists | 24 | 20% |
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Mendeley readers
Geographical breakdown
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Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 14 | 16% |
Student > Master | 14 | 16% |
Student > Bachelor | 7 | 8% |
Student > Doctoral Student | 6 | 7% |
Other | 12 | 14% |
Unknown | 17 | 20% |
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Environmental Science | 2 | 2% |
Medicine and Dentistry | 2 | 2% |
Other | 6 | 7% |
Unknown | 24 | 28% |