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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Lysine Acetylation Targets Protein Complexes and Co-Regulates Major Cellular Functions
|
|---|---|
| Published in |
Science, July 2009
|
| DOI | 10.1126/science.1175371 |
| Pubmed ID | |
| Authors |
Chunaram Choudhary, Chanchal Kumar, Florian Gnad, Michael L. Nielsen, Michael Rehman, Tobias C. Walther, Jesper V. Olsen, Matthias Mann |
| Abstract |
Lysine acetylation is a reversible posttranslational modification of proteins and plays a key role in regulating gene expression. Technological limitations have so far prevented a global analysis of lysine acetylation's cellular roles. We used high-resolution mass spectrometry to identify 3600 lysine acetylation sites on 1750 proteins and quantified acetylation changes in response to the deacetylase inhibitors suberoylanilide hydroxamic acid and MS-275. Lysine acetylation preferentially targets large macromolecular complexes involved in diverse cellular processes, such as chromatin remodeling, cell cycle, splicing, nuclear transport, and actin nucleation. Acetylation impaired phosphorylation-dependent interactions of 14-3-3 and regulated the yeast cyclin-dependent kinase Cdc28. Our data demonstrate that the regulatory scope of lysine acetylation is broad and comparable with that of other major posttranslational modifications. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 2,717 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 36 | 1% |
| United Kingdom | 19 | <1% |
| Germany | 15 | <1% |
| France | 10 | <1% |
| Netherlands | 6 | <1% |
| Japan | 6 | <1% |
| Canada | 6 | <1% |
| Argentina | 5 | <1% |
| Spain | 4 | <1% |
| Other | 47 | 2% |
| Unknown | 2563 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 712 | 26% |
| Researcher | 517 | 19% |
| Student > Master | 280 | 10% |
| Student > Bachelor | 266 | 10% |
| Professor > Associate Professor | 124 | 5% |
| Other | 377 | 14% |
| Unknown | 441 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 975 | 36% |
| Biochemistry, Genetics and Molecular Biology | 670 | 25% |
| Chemistry | 188 | 7% |
| Medicine and Dentistry | 141 | 5% |
| Pharmacology, Toxicology and Pharmaceutical Science | 51 | 2% |
| Other | 194 | 7% |
| Unknown | 498 | 18% |
Attention Score in Context
This research output has an Altmetric Attention Score of 27. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 February 2024.
All research outputs
#1,442,585
of 25,373,627 outputs
Outputs from Science
#23,559
of 82,915 outputs
Outputs of similar age
#4,259
of 122,236 outputs
Outputs of similar age from Science
#80
of 387 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 82,915 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 65.7. This one has gotten more attention than average, scoring higher than 71% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 122,236 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 387 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 79% of its contemporaries.