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SDHA mutated paragangliomas may be at high risk of metastasis

Overview of attention for article published in Endocrine-Related Cancer, May 2017
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Title
SDHA mutated paragangliomas may be at high risk of metastasis
Published in
Endocrine-Related Cancer, May 2017
DOI 10.1530/erc-17-0030
Pubmed ID
Authors

Nicola Tufton, Rahul Ghelani, Umasuthan Srirangalingam, Ajith V Kumar, William M Drake, Donato Iacovazzo, Kassiani Skordilis, Daniel Berney, Ma'en Al-Mrayat, Bernard Khoo, Scott A Akker

Abstract

We report the clinical outcomes of eleven patients with succinate dehydrogenase subunit A (SDHA) germline mutations from three UK tertiary referral centres to highlight a more diverse and expanding clinical spectrum of associated phenotypes. We suggest that SDHA paraganglioma related disease is not a low risk condition as first described. Of our six index cases, two developed metastatic disease and a further one had local vascular invasion. One patient developed multiple metachronous disease. Therefore, we believe these patients, like those with SDHB & SDHD mutations, should be part of a surveillance programme.

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The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 8 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 8 100%

Demographic breakdown

Readers by professional status Count As %
Student > Postgraduate 2 25%
Student > Ph. D. Student 1 13%
Student > Bachelor 1 13%
Professor > Associate Professor 1 13%
Unknown 3 38%
Readers by discipline Count As %
Medicine and Dentistry 4 50%
Unknown 4 50%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 May 2018.
All research outputs
#22,764,772
of 25,382,440 outputs
Outputs from Endocrine-Related Cancer
#1,407
of 1,509 outputs
Outputs of similar age
#284,274
of 324,616 outputs
Outputs of similar age from Endocrine-Related Cancer
#24
of 25 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,509 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.1. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 25 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.