Title |
Cross-talk between bile acids and intestinal microbiota in host metabolism and health
|
---|---|
Published in |
Journal of Zhejiang University - Science B, May 2015
|
DOI | 10.1631/jzus.b1400327 |
Pubmed ID | |
Authors |
Yang-fan Nie, Jun Hu, Xiang-hua Yan |
Abstract |
Bile acid (BA) is de novo synthesized exclusively in the liver and has direct or indirect antimicrobial effects. On the other hand, the composition and size of the BA pool can be altered by intestinal microbiota via the biotransformation of primary BAs to secondary BAs, and subsequently regulate the nuclear farnesoid X receptor (FXR; NR1H4). The BA-activated FXR plays important roles in BA synthesis and metabolism, glucose and lipid metabolism, and even hepatic autophagy. BAs can also play a role in the interplays among intestinal microbes. In this review, we mainly discuss the interactions between BAs and intestinal microbiota and their roles in regulating host metabolism, and probably the autophagic signaling pathway. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 6 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 5 | 83% |
Practitioners (doctors, other healthcare professionals) | 1 | 17% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 182 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 39 | 21% |
Researcher | 28 | 15% |
Student > Master | 19 | 10% |
Student > Bachelor | 18 | 10% |
Student > Doctoral Student | 11 | 6% |
Other | 30 | 16% |
Unknown | 37 | 20% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 39 | 21% |
Biochemistry, Genetics and Molecular Biology | 31 | 17% |
Medicine and Dentistry | 28 | 15% |
Immunology and Microbiology | 19 | 10% |
Engineering | 4 | 2% |
Other | 18 | 10% |
Unknown | 43 | 24% |