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Mendeley readers
Attention Score in Context
| Title |
Presence of a Potent Transcription Activating Sequence in the p53 Protein
|
|---|---|
| Published in |
Science, August 1990
|
| DOI | 10.1126/science.2144363 |
| Pubmed ID | |
| Authors |
Stanley Fields, Sung Key Jang |
| Abstract |
The p53 gene is frequently mutated in a wide variety of human cancers. However, the role of the wild-type p53 gene in growth control is not known. Hybrid proteins that contain the DNA binding domain of yeast GAL4 and portions of p53 have been used to show that the p53 protein contains a transcription-activating sequence that functions in both yeast and mammalian cells. The NH2-terminal 73 residues of p53 activated transcription in mammalian cells as efficiently as the herpes virus protein VP16, which contains one of the strongest known activation domains. Combined with previous data that showed p53 is localized to the nucleus and can bind to DNA, these results support the idea that one function of p53 is to activate the transcription of genes that suppress cell proliferation. |
Mendeley readers
The data shown below were compiled from readership statistics for 105 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 1 | <1% |
| United Kingdom | 1 | <1% |
| United States | 1 | <1% |
| Germany | 1 | <1% |
| Unknown | 101 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 24 | 23% |
| Student > Bachelor | 16 | 15% |
| Researcher | 12 | 11% |
| Student > Master | 9 | 9% |
| Student > Doctoral Student | 6 | 6% |
| Other | 19 | 18% |
| Unknown | 19 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 31 | 30% |
| Agricultural and Biological Sciences | 30 | 29% |
| Medicine and Dentistry | 14 | 13% |
| Chemistry | 4 | 4% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | <1% |
| Other | 5 | 5% |
| Unknown | 20 | 19% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 January 2006.
All research outputs
#7,557,454
of 23,052,509 outputs
Outputs from Science
#48,244
of 78,178 outputs
Outputs of similar age
#4,374
of 15,489 outputs
Outputs of similar age from Science
#99
of 171 outputs
Altmetric has tracked 23,052,509 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 78,178 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 62.5. This one is in the 21st percentile – i.e., 21% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 15,489 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 8th percentile – i.e., 8% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 171 others from the same source and published within six weeks on either side of this one. This one is in the 4th percentile – i.e., 4% of its contemporaries scored the same or lower than it.