| Title |
Is the Alzheimer’s disease cortical thickness signature a biological marker for memory?
|
|---|---|
| Published in |
Brain Imaging and Behavior, June 2015
|
| DOI | 10.1007/s11682-015-9413-5 |
| Pubmed ID | |
| Authors |
Edgar Busovaca, Molly E. Zimmerman, Irene B. Meier, Erica Y. Griffith, Stuart M. Grieve, Mayuresh S. Korgaonkar, Leanne M. Williams, Adam M. Brickman |
| Abstract |
Recent work suggests that analysis of the cortical thickness in key brain regions can be used to identify individuals at greatest risk for development of Alzheimer's disease (AD). It is unclear to what extent this "signature" is a biological marker of normal memory function - the primary cognitive domain affected by AD. We examined the relationship between the AD signature biomarker and memory functioning in a group of neurologically healthy young and older adults. Cortical thickness measurements and neuropsychological evaluations were obtained in 110 adults (age range 21-78, mean = 46) drawn from the Brain Resource International Database. The cohort was divided into young adult (n = 64, age 21-50) and older adult (n = 46, age 51-78) groups. Cortical thickness analysis was performed with FreeSurfer, and the average cortical thickness extracted from the eight regions that comprise the AD signature. Mean AD-signature cortical thickness was positively associated with performance on the delayed free recall trial of a list learning task and this relationship did not differ between younger and older adults. Mean AD-signature cortical thickness was not associated with performance on a test of psychomotor speed, as a control task, in either group. The results suggest that the AD signature cortical thickness is a marker for memory functioning across the adult lifespan. |
Mendeley readers
The data shown below were compiled from readership statistics for 67 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 1 | 1% |
| Unknown | 66 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 17 | 25% |
| Student > Master | 10 | 15% |
| Student > Ph. D. Student | 9 | 13% |
| Student > Doctoral Student | 5 | 7% |
| Student > Bachelor | 4 | 6% |
| Other | 9 | 13% |
| Unknown | 13 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 13 | 19% |
| Neuroscience | 11 | 16% |
| Medicine and Dentistry | 10 | 15% |
| Agricultural and Biological Sciences | 3 | 4% |
| Computer Science | 2 | 3% |
| Other | 10 | 15% |
| Unknown | 18 | 27% |
Attention Score in Context
This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 June 2015.
All research outputs
#4,175,748
of 22,811,321 outputs
Outputs from Brain Imaging and Behavior
#234
of 1,155 outputs
Outputs of similar age
#53,340
of 267,086 outputs
Outputs of similar age from Brain Imaging and Behavior
#8
of 34 outputs
Altmetric has tracked 22,811,321 research outputs across all sources so far. Compared to these this one has done well and is in the 80th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,155 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.0. This one has done well, scoring higher than 75% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 267,086 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 78% of its contemporaries.
We're also able to compare this research output to 34 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.