Title |
Basal vitamin D levels and disease activity in multiple sclerosis patients treated with fingolimod
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Published in |
Neurological Sciences, May 2018
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DOI | 10.1007/s10072-018-3440-0 |
Pubmed ID | |
Authors |
L. Ferre’, F. Clarelli, G. Sferruzza, M. A. Rocca, E. Mascia, M. Radaelli, F. Sangalli, G. Dalla Costa, L. Moiola, M. Aboulwafa, F. Martinelli Boneschi, G. Comi, M. Filippi, V. Martinelli, F. Esposito |
Abstract |
Several studies have shown an association between 25-hydroxyvitamin D (25[OH]D) levels and multiple sclerosis (MS) susceptibility and/or level of disease activity in patients treated with first line drugs. To investigate whether baseline 25[OH]D values could influence disease activity also during treatment with the second-line drug fingolimod (FTY). We enrolled 176 MS patients who started FTY at the San Raffaele Hospital (OSR) MS center with available 25[OH]D measurement at the time of treatment start. We then prospectively followed them for 2 years with periodic clinical examinations and MRI scans. We found no linear correlation between baseline 25[OH]D levels and annualized relapse rate (ARR) or time to first relapse. However, we observed that patients with serum 25[OH]D ≥ 100 nmol/l showed a lower number of Gd+ and combined unique activity (CUA) lesions at baseline compared to patients with the lowest 25[OH]D levels (less than 50 nmol/l, p value < 0.05). Moreover, they showed fewer CUA lesions at 2-year follow-up also when accounting for baseline level of disease activity (p value < 0.05). In patients treated with FTY, those with the highest baseline 25(OH)D levels had a significantly lower number of active lesions at baseline; the same effect, even if weaker, was observed also at 2-year follow-up when adjusting for baseline disease activity. Given Vitamin D supplementation safety profile, also if a causal effect has not yet been shown, most of MS patients could probably benefit from 25[OH]D levels above those currently considered to be sufficient. |
X Demographics
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Spain | 1 | 50% |
Unknown | 1 | 50% |
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Members of the public | 2 | 100% |
Mendeley readers
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Other | 9 | 17% |
Student > Bachelor | 5 | 9% |
Student > Doctoral Student | 4 | 8% |
Student > Ph. D. Student | 4 | 8% |
Student > Postgraduate | 4 | 8% |
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Psychology | 1 | 2% |
Other | 3 | 6% |
Unknown | 20 | 38% |