| Title |
Dosierung von Antiinfektiva bei Nierenversagen und Nierenersatztherapie in der Intensivmedizin
|
|---|---|
| Published in |
Medizinische Klinik - Intensivmedizin und Notfallmedizin, March 2018
|
| DOI | 10.1007/s00063-018-0416-z |
| Pubmed ID | |
| Authors |
D. Czock, V. Schwenger, D. Kindgen-Milles, M. Joannidis, S. John, M. Schmitz, A. Jörres, A. Zarbock, M. Oppert, J. T. Kielstein, C. Willam |
| Abstract |
Many anti-infective drugs require dose adjustments in critically ill patients with acute kidney injury (AKI) and renal replacement therapy, in order to achieve adequate therapeutic drug concentrations. The fundamental pharmacokinetic and pharmacodynamic principles of drug dose adjustment are presented. Recommendations on anti-infective drug dosage in intensive care are provided. We established dose recommendations of selected anti-infective drugs based on information in the summary of product characteristics, published studies and recommendations, pharmacokinetic and pharmacodynamic considerations, and the experience and expert opinion of the authors. Out of a total of 37 anti-infective drugs (31 antibiotics, 2 antivirals, 4 antifungals) 8 can be administered independent of renal function. For 29 anti-infective drugs, a specific recommendation on drug dosage could be made in case of intermittent hemodialysis and for 24 anti-infective drugs in case of continuous hemo(dia)filtration. Recommendations on dosing of important anti-infective drugs in critically ill patients with AKI and renal replacement therapy are provided. |
Mendeley readers
The data shown below were compiled from readership statistics for 15 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 15 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Other | 4 | 27% |
| Researcher | 4 | 27% |
| Student > Bachelor | 1 | 7% |
| Student > Doctoral Student | 1 | 7% |
| Professor | 1 | 7% |
| Other | 1 | 7% |
| Unknown | 3 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 8 | 53% |
| Nursing and Health Professions | 1 | 7% |
| Unknown | 6 | 40% |
Attention Score in Context
This research output has an Altmetric Attention Score of 16. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 July 2018.
All research outputs
#1,999,214
of 23,053,169 outputs
Outputs from Medizinische Klinik - Intensivmedizin und Notfallmedizin
#18
of 540 outputs
Outputs of similar age
#45,942
of 333,792 outputs
Outputs of similar age from Medizinische Klinik - Intensivmedizin und Notfallmedizin
#1
of 26 outputs
Altmetric has tracked 23,053,169 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 540 research outputs from this source. They receive a mean Attention Score of 3.1. This one has done particularly well, scoring higher than 96% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 333,792 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 86% of its contemporaries.
We're also able to compare this research output to 26 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 92% of its contemporaries.