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The PCL2 (ORFD)-PHO85 Cyclin-Dependent Kinase Complex: a Cell Cycle Regulator in Yeast

Overview of attention for article published in Science, November 1994
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2 patents

Citations

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151 Dimensions

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54 Mendeley
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Title
The PCL2 (ORFD)-PHO85 Cyclin-Dependent Kinase Complex: a Cell Cycle Regulator in Yeast
Published in
Science, November 1994
DOI 10.1126/science.7973731
Pubmed ID
Authors

V Measday, L Moore, J Ogas, M Tyers, B Andrews

Abstract

Cyclin-dependent kinase (cdk) complexes are essential activators of cell cycle progression in all eukaryotes. In contrast to mammalian cells, in which multiple cdk's contribute to cell cycle regulation, the yeast cell cycle is largely controlled by the activity of a single cdk, CDC28. Analysis of the putative G1 cyclin PCL2 (ORFD) identified a second cyclin-cdk complex that contributes to cell cycle progression in yeast. PCL2 interacted with the cdk PHO85 in vivo and in vitro and formed a kinase complex that had G1-periodic activity. Under genetic conditions in which the Start transition was compromised, PHO85 and its associated cyclin subunits were essential for cell cycle commitment. Because PHO85 and another cyclin-like molecule, PHO80, also take part in inorganic phosphate metabolism, this cdk enzyme may integrate responses to nutritional conditions with the cell cycle.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 54 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 4%
Brazil 1 2%
Unknown 51 94%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 16 30%
Professor 7 13%
Researcher 6 11%
Student > Doctoral Student 5 9%
Student > Bachelor 3 6%
Other 5 9%
Unknown 12 22%
Readers by discipline Count As %
Agricultural and Biological Sciences 23 43%
Biochemistry, Genetics and Molecular Biology 13 24%
Medicine and Dentistry 3 6%
Engineering 2 4%
Pharmacology, Toxicology and Pharmaceutical Science 1 2%
Other 1 2%
Unknown 11 20%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 May 2002.
All research outputs
#7,557,690
of 23,053,613 outputs
Outputs from Science
#48,244
of 78,179 outputs
Outputs of similar age
#16,108
of 76,399 outputs
Outputs of similar age from Science
#114
of 212 outputs
Altmetric has tracked 23,053,613 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 78,179 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 62.5. This one is in the 21st percentile – i.e., 21% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 76,399 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 20th percentile – i.e., 20% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 212 others from the same source and published within six weeks on either side of this one. This one is in the 4th percentile – i.e., 4% of its contemporaries scored the same or lower than it.