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Phosphate-Regulated Inactivation of the Kinase PHO80-PHO85 by the CDK Inhibitor PHO81

Overview of attention for article published in Science, October 1994
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8 patents

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66 Mendeley
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Title
Phosphate-Regulated Inactivation of the Kinase PHO80-PHO85 by the CDK Inhibitor PHO81
Published in
Science, October 1994
DOI 10.1126/science.7939631
Pubmed ID
Authors

Ken R. Schneider, Rebecca L. Smith, Erin K. O'Shea

Abstract

A complex consisting of the cyclin-dependent kinase (CDK) PHO85 and the cyclin PHO80 phosphorylates and is thought to inactivate the transcription factor PHO4 when yeast cells are grown in medium containing high concentrations of phosphate. The CDK inhibitor PHO81 inhibits the kinase activity of the PHO80-PHO85 complex when Saccharomyces cerevisiae cells are grown in medium depleted of phosphate. A region of PHO81 with similarity to the mammalian CDK inhibitor p16INK4 is sufficient for inhibition in vitro. These studies demonstrate that CDK inhibitors are used to regulate kinases involved in processes other than cell cycle control and suggest that the ankyrin repeat motif may be commonly used for interaction with cyclin-CDK complexes.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 66 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 2%
Argentina 1 2%
Switzerland 1 2%
Unknown 63 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 25 38%
Researcher 12 18%
Student > Bachelor 6 9%
Professor > Associate Professor 4 6%
Student > Master 4 6%
Other 7 11%
Unknown 8 12%
Readers by discipline Count As %
Agricultural and Biological Sciences 36 55%
Biochemistry, Genetics and Molecular Biology 16 24%
Chemistry 4 6%
Medicine and Dentistry 1 2%
Immunology and Microbiology 1 2%
Other 0 0%
Unknown 8 12%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 April 2010.
All research outputs
#7,557,690
of 23,053,613 outputs
Outputs from Science
#48,244
of 78,179 outputs
Outputs of similar age
#6,544
of 22,197 outputs
Outputs of similar age from Science
#125
of 223 outputs
Altmetric has tracked 23,053,613 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 78,179 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 62.5. This one is in the 21st percentile – i.e., 21% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 22,197 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 8th percentile – i.e., 8% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 223 others from the same source and published within six weeks on either side of this one. This one is in the 4th percentile – i.e., 4% of its contemporaries scored the same or lower than it.