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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Genome-wide significant risk associations for mucinous ovarian carcinoma
|
|---|---|
| Published in |
Nature Genetics, June 2015
|
| DOI | 10.1038/ng.3336 |
| Pubmed ID | |
| Abstract |
Genome-wide association studies have identified several risk associations for ovarian carcinomas but not for mucinous ovarian carcinomas (MOCs). Our analysis of 1,644 MOC cases and 21,693 controls with imputation identified 3 new risk associations: rs752590 at 2q13 (P = 3.3 × 10(-8)), rs711830 at 2q31.1 (P = 7.5 × 10(-12)) and rs688187 at 19q13.2 (P = 6.8 × 10(-13)). We identified significant expression quantitative trait locus (eQTL) associations for HOXD9 at 2q31.1 in ovarian (P = 4.95 × 10(-4), false discovery rate (FDR) = 0.003) and colorectal (P = 0.01, FDR = 0.09) tumors and for PAX8 at 2q13 in colorectal tumors (P = 0.03, FDR = 0.09). Chromosome conformation capture analysis identified interactions between the HOXD9 promoter and risk-associated SNPs at 2q31.1. Overexpressing HOXD9 in MOC cells augmented the neoplastic phenotype. These findings provide the first evidence for MOC susceptibility variants and insights into the underlying biology of the disease. |
X Demographics
The data shown below were collected from the profiles of 30 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 11 | 37% |
| Australia | 2 | 7% |
| Canada | 2 | 7% |
| Spain | 1 | 3% |
| United Kingdom | 1 | 3% |
| India | 1 | 3% |
| Unknown | 12 | 40% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 15 | 50% |
| Scientists | 11 | 37% |
| Science communicators (journalists, bloggers, editors) | 3 | 10% |
| Practitioners (doctors, other healthcare professionals) | 1 | 3% |
Mendeley readers
The data shown below were compiled from readership statistics for 91 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | 1% |
| France | 1 | 1% |
| Thailand | 1 | 1% |
| Unknown | 88 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 19 | 21% |
| Student > Ph. D. Student | 15 | 16% |
| Student > Master | 10 | 11% |
| Professor | 9 | 10% |
| Student > Doctoral Student | 5 | 5% |
| Other | 18 | 20% |
| Unknown | 15 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 26 | 29% |
| Agricultural and Biological Sciences | 17 | 19% |
| Biochemistry, Genetics and Molecular Biology | 15 | 16% |
| Immunology and Microbiology | 3 | 3% |
| Physics and Astronomy | 2 | 2% |
| Other | 7 | 8% |
| Unknown | 21 | 23% |
Attention Score in Context
This research output has an Altmetric Attention Score of 80. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 November 2021.
All research outputs
#544,746
of 25,837,817 outputs
Outputs from Nature Genetics
#1,079
of 7,639 outputs
Outputs of similar age
#5,888
of 280,819 outputs
Outputs of similar age from Nature Genetics
#19
of 84 outputs
Altmetric has tracked 25,837,817 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 7,639 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 43.7. This one has done well, scoring higher than 85% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 280,819 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 84 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 77% of its contemporaries.