| Title |
The Role of Inflammation in Nonspecific Abdominal Aortic Aneurysm Disease
|
|---|---|
| Published in |
Annals of Vascular Surgery (Science Direct), May 1991
|
| DOI | 10.1007/bf02329378 |
| Pubmed ID | |
| Authors |
Colleen M. Brophy, Jeffrey M. Reilly, G.J. Walker Smith, M. David Tilson |
| Abstract |
The predominant pathologic feature of abdominal aortic aneurysm is elastin destruction, and elastin destruction may be mediated by inflammation. In this investigation serial sections of abdominal aortic aneurysm specimens were selectively stained to study the relationship between inflammation and elastin degradation. In addition, soluble aortic extracts were examined for the presence of immunoglobulins. An inflammatory infiltrate was present in 8 of 10 of the abdominal aortic aneurysm specimens examined. The infiltrate was mononuclear, commonly located at the junction of the media and adventitia; it did not codistribute with loss of elastin. The presence of an inflammatory component in abdominal aortic aneurysm was associated with a large amount of immunoglobulin in soluble extracts from aneurysmal tissue compared to atherosclerotic and normal control extracts. This study further characterizes the microscopic pathology of abdominal aortic aneurysm and describes the presence of immunoglobulin in soluble tissue extracts. In addition, the possible role of inflammation in abdominal aortic aneurysm as it relates to protease expression is detailed. |
Mendeley readers
The data shown below were compiled from readership statistics for 43 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 2% |
| Unknown | 42 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 9 | 21% |
| Student > Ph. D. Student | 8 | 19% |
| Student > Bachelor | 5 | 12% |
| Student > Postgraduate | 3 | 7% |
| Student > Master | 3 | 7% |
| Other | 7 | 16% |
| Unknown | 8 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 14 | 33% |
| Engineering | 7 | 16% |
| Agricultural and Biological Sciences | 6 | 14% |
| Biochemistry, Genetics and Molecular Biology | 2 | 5% |
| Neuroscience | 1 | 2% |
| Other | 0 | 0% |
| Unknown | 13 | 30% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 September 2006.
All research outputs
#5,447,195
of 25,374,917 outputs
Outputs from Annals of Vascular Surgery (Science Direct)
#219
of 2,011 outputs
Outputs of similar age
#2,048
of 16,405 outputs
Outputs of similar age from Annals of Vascular Surgery (Science Direct)
#2
of 2 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. Compared to these this one has done well and is in the 75th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,011 research outputs from this source. They receive a mean Attention Score of 3.6. This one has done well, scoring higher than 88% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 16,405 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.
We're also able to compare this research output to 2 others from the same source and published within six weeks on either side of this one.