| Title |
Chitosan/gelatin scaffolds support bone regeneration
|
|---|---|
| Published in |
Journal of Materials Science: Materials in Medicine, May 2018
|
| DOI | 10.1007/s10856-018-6064-2 |
| Pubmed ID | |
| Authors |
Anthie Georgopoulou, Fotios Papadogiannis, Aristea Batsali, John Marakis, Kalliopi Alpantaki, Aristides G. Eliopoulos, Charalampos Pontikoglou, Maria Chatzinikolaidou |
| Abstract |
Chitosan/Gelatin (CS:Gel) scaffolds were fabricated by chemical crosslinking with glutaraldehyde or genipin by freeze drying. Both crosslinked CS:Gel scaffold types with a mass ratio of 40:60% form a gel-like structure with interconnected pores. Dynamic rheological measurements provided similar values for the storage modulus and the loss modulus of the CS:Gel scaffolds when crosslinked with the same concentration of glutaraldehyde vs. genipin. Compared to genipin, the glutaraldehyde-crosslinked scaffolds supported strong adhesion and infiltration of pre-osteoblasts within the pores as well as survival and proliferation of both MC3T3-E1 pre-osteoblastic cells after 7 days in culture, and human bone marrow mesenchymal stem cells (BM-MSCs) after 14 days in culture. The levels of collagen secreted into the extracellular matrix by the pre-osteoblasts cultured for 4 and 7 days on the CS:Gel scaffolds, significantly increased when compared to the tissue culture polystyrene (TCPS) control surface. Human BM-MSCs attached and infiltrated within the pores of the CS:Gel scaffolds allowing for a significant increase of the osteogenic gene expression of RUNX2, ALP, and OSC. Histological data following implantation of a CS:Gel scaffold into a mouse femur demonstrated that the scaffolds support the formation of extracellular matrix, while fibroblasts surrounding the porous scaffold produce collagen with minimal inflammatory reaction. These results show the potential of CS:Gel scaffolds to support new tissue formation and thus provide a promising strategy for bone tissue engineering. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Science communicators (journalists, bloggers, editors) | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 106 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 106 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 15 | 14% |
| Student > Bachelor | 12 | 11% |
| Researcher | 8 | 8% |
| Student > Ph. D. Student | 8 | 8% |
| Professor > Associate Professor | 4 | 4% |
| Other | 14 | 13% |
| Unknown | 45 | 42% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 13 | 12% |
| Engineering | 11 | 10% |
| Materials Science | 8 | 8% |
| Biochemistry, Genetics and Molecular Biology | 7 | 7% |
| Pharmacology, Toxicology and Pharmaceutical Science | 5 | 5% |
| Other | 15 | 14% |
| Unknown | 47 | 44% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 May 2018.
All research outputs
#18,612,022
of 23,055,429 outputs
Outputs from Journal of Materials Science: Materials in Medicine
#1,189
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Outputs of similar age
#253,600
of 327,167 outputs
Outputs of similar age from Journal of Materials Science: Materials in Medicine
#11
of 14 outputs
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