Title |
Innovative Research Design to Meet the Challenges of Clinical Trials for Juvenile Dermatomyositis
|
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Published in |
Current Rheumatology Reports, April 2018
|
DOI | 10.1007/s11926-018-0734-4 |
Pubmed ID | |
Authors |
Silvia Rosina, Giulia Camilla Varnier, Marta Mazzoni, Stefano Lanni, Clara Malattia, Angelo Ravelli |
Abstract |
This paper aims to provide a summary of the recent therapeutic advances and the latest research on outcome measures for clinical trials in juvenile dermatomyositis (JDM). Recent randomized controlled trials (RCTs) have demonstrated the superiority of the combination of prednisone with methotrexate over other conventional therapies and the potential effectiveness of rituximab in refractory cases. A multinational project has led to develop new criteria for the definition of minimal, moderate, and major improvement in future JDM clinical trials. This effort has been paralleled by the establishment of criteria for clinically inactive disease. The validation of the first composite disease activity score for JDM is in progress. The new outcome measures will increase the reliability of assessment of clinical response in JDM clinical trials and foster future multinational RCTs aimed to investigate novel treatment strategies for refractory forms of JDM. |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 21 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Doctoral Student | 4 | 19% |
Other | 3 | 14% |
Student > Ph. D. Student | 3 | 14% |
Researcher | 2 | 10% |
Student > Bachelor | 2 | 10% |
Other | 4 | 19% |
Unknown | 3 | 14% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 10 | 48% |
Immunology and Microbiology | 5 | 24% |
Nursing and Health Professions | 1 | 5% |
Agricultural and Biological Sciences | 1 | 5% |
Unknown | 4 | 19% |