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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Global and local ancestry in African‐Americans: Implications for Alzheimer's disease risk
|
|---|---|
| Published in |
Alzheimer's & Dementia: the Journal of the Alzheimer's Association, June 2015
|
| DOI | 10.1016/j.jalz.2015.02.012 |
| Pubmed ID | |
| Authors |
Timothy J. Hohman, Jessica N. Cooke‐Bailey, Christiane Reitz, Gyungah Jun, Adam Naj, Gary W. Beecham, Zhi Liu, Regina M. Carney, Jeffrey M. Vance, Michael L. Cuccaro, Ruchita Rajbhandary, Badri Narayan Vardarajan, Li‐San Wang, Otto Valladares, Chiao‐Feng Lin, Eric B. Larson, Neill R. Graff‐Radford, Denis Evans, Philip L. De Jager, Paul K. Crane, Joseph D. Buxbaum, Jill R. Murrell, Towfique Raj, Nilufer Ertekin‐Taner, Mark W. Logue, Clinton T. Baldwin, Robert C. Green, Lisa L. Barnes, Laura B. Cantwell, M. Daniele Fallin, Rodney C.P. Go, Patrick Griffith, Thomas O. Obisesan, Jennifer J. Manly, Kathryn L. Lunetta, M. Ilyas Kamboh, Oscar L. Lopez, David A. Bennett, John Hardy, Hugh C. Hendrie, Kathleen S. Hall, Alison M. Goate, Rosalyn Lang, Goldie S. Byrd, Walter A. Kukull, Tatiana M. Foroud, Lindsay A. Farrer, Eden R. Martin, Margaret A. Pericak‐Vance, Gerard D. Schellenberg, Richard Mayeux, Jonathan L. Haines, Tricia A. Thornton‐Wells, Alzheimer Disease Genetics Consortium |
| Abstract |
African-American (AA) individuals have a higher risk for late-onset Alzheimer's disease (LOAD) than Americans of primarily European ancestry (EA). Recently, the largest genome-wide association study in AAs to date confirmed that six of the Alzheimer's disease (AD)-related genetic variants originally discovered in EA cohorts are also risk variants in AA; however, the risk attributable to many of the loci (e.g., APOE, ABCA7), differed substantially from previous studies in EA. There likely are risk variants of higher frequency in AAs that have not been discovered. We performed a comprehensive analysis of genetically determined local and global ancestry in AAs with regard to LOAD status. Compared to controls, LOAD cases showed higher levels of African ancestry, both globally and at several LOAD relevant loci, which explained risk for AD beyond global differences. Exploratory post hoc analyses highlight regions with greatest differences in ancestry as potential candidate regions for future genetic analyses. |
X Demographics
The data shown below were collected from the profiles of 13 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 4 | 31% |
| Denmark | 1 | 8% |
| Unknown | 8 | 62% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 10 | 77% |
| Scientists | 2 | 15% |
| Unknown | 1 | 8% |
Mendeley readers
The data shown below were compiled from readership statistics for 116 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | <1% |
| Colombia | 1 | <1% |
| Unknown | 114 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 22 | 19% |
| Student > Bachelor | 21 | 18% |
| Student > Ph. D. Student | 9 | 8% |
| Student > Master | 9 | 8% |
| Other | 8 | 7% |
| Other | 19 | 16% |
| Unknown | 28 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 15 | 13% |
| Agricultural and Biological Sciences | 15 | 13% |
| Medicine and Dentistry | 13 | 11% |
| Neuroscience | 11 | 9% |
| Psychology | 8 | 7% |
| Other | 23 | 20% |
| Unknown | 31 | 27% |
Attention Score in Context
This research output has an Altmetric Attention Score of 31. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 November 2019.
All research outputs
#1,280,482
of 25,394,764 outputs
Outputs from Alzheimer's & Dementia: the Journal of the Alzheimer's Association
#582
of 4,063 outputs
Outputs of similar age
#14,760
of 264,223 outputs
Outputs of similar age from Alzheimer's & Dementia: the Journal of the Alzheimer's Association
#10
of 101 outputs
Altmetric has tracked 25,394,764 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,063 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 32.3. This one has done well, scoring higher than 85% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 264,223 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 94% of its contemporaries.
We're also able to compare this research output to 101 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 90% of its contemporaries.