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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Cytokine-Mediated Loss of Blood Dendritic Cells During Epstein-Barr Virus–Associated Acute Infectious Mononucleosis: Implication for Immune Dysregulation
|
|---|---|
| Published in |
Journal of Infectious Diseases, June 2015
|
| DOI | 10.1093/infdis/jiv340 |
| Pubmed ID | |
| Authors |
Archana Panikkar, Corey Smith, Andrew Hislop, Nick Tellam, Vijayendra Dasari, Kristin A. Hogquist, Michelle Wykes, Denis J. Moss, Alan Rickinson, Henry H. Balfour, Rajiv Khanna |
| Abstract |
Acute infectious mononucleosis (IM) is associated with altered expression of inflammatory cytokines and disturbed T cell homeostasis, however, the precise mechanism of this immune dysregulation remains unresolved. Here we show that a significant loss of circulating myeloid and plasmacytoid DCs is observed during acute IM and this loss correlated with the severity of clinical symptoms. Interestingly, in vitro exposure of blood DCs to acute IM plasma resulted in loss of pDCs and further studies with individual cytokines showed that IL-10 exposure could replicate this effect. Our data provides important mechanistic insight on dysregulated immune homeostasis during acute IM. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 25% |
| Germany | 1 | 25% |
| Unknown | 2 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 50% |
| Scientists | 1 | 25% |
| Science communicators (journalists, bloggers, editors) | 1 | 25% |
Mendeley readers
The data shown below were compiled from readership statistics for 24 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 24 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 4 | 17% |
| Researcher | 4 | 17% |
| Student > Doctoral Student | 3 | 13% |
| Other | 3 | 13% |
| Student > Ph. D. Student | 3 | 13% |
| Other | 3 | 13% |
| Unknown | 4 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Immunology and Microbiology | 6 | 25% |
| Biochemistry, Genetics and Molecular Biology | 4 | 17% |
| Medicine and Dentistry | 4 | 17% |
| Computer Science | 2 | 8% |
| Mathematics | 1 | 4% |
| Other | 2 | 8% |
| Unknown | 5 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 March 2016.
All research outputs
#14,915,476
of 25,377,790 outputs
Outputs from Journal of Infectious Diseases
#11,660
of 14,793 outputs
Outputs of similar age
#124,208
of 264,137 outputs
Outputs of similar age from Journal of Infectious Diseases
#79
of 137 outputs
Altmetric has tracked 25,377,790 research outputs across all sources so far. This one is in the 40th percentile – i.e., 40% of other outputs scored the same or lower than it.
So far Altmetric has tracked 14,793 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 16.4. This one is in the 20th percentile – i.e., 20% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 264,137 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 52% of its contemporaries.
We're also able to compare this research output to 137 others from the same source and published within six weeks on either side of this one. This one is in the 42nd percentile – i.e., 42% of its contemporaries scored the same or lower than it.