Title |
Short‐term modern life‐like stress exacerbates Aβ‐pathology and synapse loss in 3xTg‐AD mice
|
---|---|
Published in |
Journal of Neurochemistry, July 2015
|
DOI | 10.1111/jnc.13195 |
Pubmed ID | |
Authors |
David Baglietto-Vargas, Yuncai Chen, Dongjin Suh, Rahasson R Ager, Carlos J Rodriguez-Ortiz, Rodrigo Medeiros, Kristoffer Myczek, Kim N Green, Tallie Z Baram, Frank M LaFerla |
Abstract |
Alzheimer's disease (AD) is a progressive neurological disorder that impairs memory and other cognitive functions in the elderly. The social and financial impacts of AD are overwhelming and are escalating exponentially as a result of population aging. Therefore, identifying AD-related risk factors and the development of more efficacious therapeutic approaches are critical to cure this neurological disorder. Current epidemiological evidence indicates that life experiences, including chronic stress, are a risk for AD. However, it is unknown if short-term stress, lasting for hours, influences the onset or progression of AD. Here, we determined the effect of short-term, multi-modal 'modern life-like' stress on AD pathogenesis and synaptic plasticity in mice bearing three AD mutations (the 3xTg-AD mouse model). We found that combined emotional and physical stress lasting 5 hours severely impaired memory in wild-type mice and tended to impact it in already low-performing 3xTg-AD mice. This stress reduced the number of synapse-bearing dendritic spines in 3xTg-AD mice and increased Aβ levels by augmenting AβPP processing. Thus, short-term stress simulating modern-life conditions may exacerbate cognitive deficits in preclinical AD by accelerating amyloid pathology and reducing synapse numbers. This article is protected by copyright. All rights reserved. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
India | 1 | 33% |
Germany | 1 | 33% |
Unknown | 1 | 33% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Practitioners (doctors, other healthcare professionals) | 1 | 33% |
Science communicators (journalists, bloggers, editors) | 1 | 33% |
Members of the public | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Spain | 3 | 2% |
Canada | 1 | <1% |
Netherlands | 1 | <1% |
Japan | 1 | <1% |
United States | 1 | <1% |
Unknown | 150 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 30 | 19% |
Student > Master | 25 | 16% |
Student > Bachelor | 19 | 12% |
Researcher | 14 | 9% |
Student > Doctoral Student | 9 | 6% |
Other | 23 | 15% |
Unknown | 37 | 24% |
Readers by discipline | Count | As % |
---|---|---|
Neuroscience | 46 | 29% |
Agricultural and Biological Sciences | 21 | 13% |
Psychology | 12 | 8% |
Medicine and Dentistry | 12 | 8% |
Biochemistry, Genetics and Molecular Biology | 7 | 4% |
Other | 11 | 7% |
Unknown | 48 | 31% |