Title |
Successful Sequential Treatment with Itraconazole and ALA-PDT for Cutaneous Granuloma by Candida albicans: A Case Report and Literature Review
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Published in |
Mycopathologia, May 2018
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DOI | 10.1007/s11046-018-0267-4 |
Pubmed ID | |
Authors |
Qing Cai, Lian-juan Yang, Jia Chen, Hong Yang, Zhi-qin Gao, Xiu-li Wang |
Abstract |
Photodynamic therapy (PDT) is a process that combines a photosensitizing drug and light and promotes phototoxic responses in target cells, mainly via oxidative damage. Antifungal photodynamic therapy has been successfully employed against Candida species, dermatophytes, and deep mycoses. We present a case of a cutaneous granuloma caused by C. albicans treated with 5-aminolevulinic acid (ALA)-PDT. A 64-year-old man presented with two plaques on his right hand and wrist for 2 years. The diagnosis was made based on histopathology, mycology, and molecular identification of paraffin-embedded tissues. The patient was treated with itraconazole for 1 month and two sessions of ALA-PDT. After 2 months of follow-up, the patient was cured and has not experienced any recurrence to date. ALA-PDT was well tolerated in this patient with little pain. In general, application of PDT in mycoses is safe and effective in most cases. ALA-PDT is a good choice for inactivation of C. albicans. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 27 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 5 | 19% |
Student > Bachelor | 5 | 19% |
Researcher | 3 | 11% |
Student > Master | 3 | 11% |
Other | 2 | 7% |
Other | 0 | 0% |
Unknown | 9 | 33% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 5 | 19% |
Biochemistry, Genetics and Molecular Biology | 3 | 11% |
Immunology and Microbiology | 3 | 11% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 4% |
Environmental Science | 1 | 4% |
Other | 3 | 11% |
Unknown | 11 | 41% |