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Interplay of cell–cell contacts and RhoA/MRTF‐A signaling regulates cardiomyocyte identity

Overview of attention for article published in EMBO Journal, May 2018
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  • Good Attention Score compared to outputs of the same age (66th percentile)

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Title
Interplay of cell–cell contacts and RhoA/MRTF‐A signaling regulates cardiomyocyte identity
Published in
EMBO Journal, May 2018
DOI 10.15252/embj.201798133
Pubmed ID
Authors

Tatjana Dorn, Jessica Kornherr, Elvira I Parrotta, Dorota Zawada, Harold Ayetey, Gianluca Santamaria, Laura Iop, Elisa Mastantuono, Daniel Sinnecker, Alexander Goedel, Ralf J Dirschinger, Ilaria My, Svenja Laue, Tarik Bozoglu, Christian Baarlink, Tilman Ziegler, Elisabeth Graf, Rabea Hinkel, Giovanni Cuda, Stefan Kääb, Andrew A Grace, Robert Grosse, Christian Kupatt, Thomas Meitinger, Austin G Smith, Karl‐Ludwig Laugwitz, Alessandra Moretti

Abstract

Cell-cell and cell-matrix interactions guide organ development and homeostasis by controlling lineage specification and maintenance, but the underlying molecular principles are largely unknown. Here, we show that in human developing cardiomyocytes cell-cell contacts at the intercalated disk connect to remodeling of the actin cytoskeleton by regulating the RhoA-ROCK signaling to maintain an active MRTF/SRF transcriptional program essential for cardiomyocyte identity. Genetic perturbation of this mechanosensory pathway activates an ectopic fat gene program during cardiomyocyte differentiation, which ultimately primes the cells to switch to the brown/beige adipocyte lineage in response to adipogenesis-inducing signals. We also demonstrate by in vivo fate mapping and clonal analysis of cardiac progenitors that cardiac fat and a subset of cardiac muscle arise from a common precursor expressing Isl1 and Wt1 during heart development, suggesting related mechanisms of determination between the two lineages.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 85 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 85 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 17 20%
Researcher 13 15%
Student > Master 9 11%
Student > Bachelor 8 9%
Other 4 5%
Other 11 13%
Unknown 23 27%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 26 31%
Agricultural and Biological Sciences 12 14%
Medicine and Dentistry 10 12%
Engineering 3 4%
Neuroscience 2 2%
Other 4 5%
Unknown 28 33%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 December 2019.
All research outputs
#7,060,650
of 25,411,814 outputs
Outputs from EMBO Journal
#6,011
of 12,117 outputs
Outputs of similar age
#114,016
of 340,993 outputs
Outputs of similar age from EMBO Journal
#57
of 67 outputs
Altmetric has tracked 25,411,814 research outputs across all sources so far. This one has received more attention than most of these and is in the 71st percentile.
So far Altmetric has tracked 12,117 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.7. This one has gotten more attention than average, scoring higher than 50% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 340,993 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 66% of its contemporaries.
We're also able to compare this research output to 67 others from the same source and published within six weeks on either side of this one. This one is in the 14th percentile – i.e., 14% of its contemporaries scored the same or lower than it.