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Mutation of the S and 3c genes in genomes of feline coronaviruses

Overview of attention for article published in Journal of Veterinary Medical Science, May 2018
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Title
Mutation of the S and 3c genes in genomes of feline coronaviruses
Published in
Journal of Veterinary Medical Science, May 2018
DOI 10.1292/jvms.17-0704
Pubmed ID
Authors

Keisuke OGUMA, OHNO Megumi, Mayuko YOSHIDA, Hiroshi SENTSUI

Abstract

Feline coronavirus (FCoV) is classified into two biotypes based on its pathogenicity in cats: a feline enteric coronavirus of low pathogenicity and a highly virulent feline infectious peritonitis virus. It has been suspected that FCoV alters its biotype via mutations in the viral genome. The S and 3c genes of FCoV have been considered the candidates for viral pathogenicity conversion. In the present study, FCoVs were analyzed for the frequency and location of mutations in the S and 3c genes from faecal samples of cats in an animal shelter and the faeces, effusions, and tissues of cats that were referred to veterinary hospitals. Our results indicated that approximately 95% FCoVs in faeces did not carry mutations in the two genes. However, 80% FCoVs in effusion samples exhibited mutations in the S and 3c genes with remainder displaying a mutation in the S or 3c gene. It was also suggested that mutational analysis of the 3c gene could be useful for studying the horizontal transmission of FCoVs in multi-cat environments.

X Demographics

X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 30 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 30 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 5 17%
Student > Ph. D. Student 3 10%
Student > Bachelor 3 10%
Student > Postgraduate 2 7%
Professor > Associate Professor 2 7%
Other 6 20%
Unknown 9 30%
Readers by discipline Count As %
Veterinary Science and Veterinary Medicine 9 30%
Biochemistry, Genetics and Molecular Biology 3 10%
Agricultural and Biological Sciences 2 7%
Medicine and Dentistry 2 7%
Nursing and Health Professions 1 3%
Other 3 10%
Unknown 10 33%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 May 2018.
All research outputs
#16,728,456
of 25,382,440 outputs
Outputs from Journal of Veterinary Medical Science
#1,216
of 3,547 outputs
Outputs of similar age
#209,628
of 342,434 outputs
Outputs of similar age from Journal of Veterinary Medical Science
#19
of 83 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. This one is in the 32nd percentile – i.e., 32% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,547 research outputs from this source. They receive a mean Attention Score of 2.5. This one has gotten more attention than average, scoring higher than 62% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 342,434 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 35th percentile – i.e., 35% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 83 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 69% of its contemporaries.