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X Demographics
Mendeley readers
Attention Score in Context
| Title |
GM-CSF Mouse Bone Marrow Cultures Comprise a Heterogeneous Population of CD11c+MHCII+ Macrophages and Dendritic Cells
|
|---|---|
| Published in |
Immunity, June 2015
|
| DOI | 10.1016/j.immuni.2015.05.018 |
| Pubmed ID | |
| Authors |
Julie Helft, Jan Böttcher, Probir Chakravarty, Santiago Zelenay, Jatta Huotari, Barbara U. Schraml, Delphine Goubau, Caetano Reis e Sousa |
| Abstract |
Dendritic cells (DCs) are key players in the immune system. Much of their biology has been elucidated via culture systems in which hematopoietic precursors differentiate into DCs under the aegis of cytokines. A widely used protocol involves the culture of murine bone marrow (BM) cells with granulocyte-macrophage colony-stimulating factor (GM-CSF) to generate BM-derived DCs (BMDCs). BMDCs express CD11c and MHC class II (MHCII) molecules and share with DCs isolated from tissues the ability to present exogenous antigens to T cells and to respond to microbial stimuli by undergoing maturation. We demonstrate that CD11c(+)MHCII(+) BMDCs are in fact a heterogeneous group of cells that comprises conventional DCs and monocyte-derived macrophages. DCs and macrophages in GM-CSF cultures both undergo maturation upon stimulation with lipopolysaccharide but respond differentially to the stimulus and remain separable entities. These results have important implications for the interpretation of a vast array of data obtained with DC culture systems. |
X Demographics
The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| France | 1 | 20% |
| United States | 1 | 20% |
| United Kingdom | 1 | 20% |
| Unknown | 2 | 40% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 80% |
| Science communicators (journalists, bloggers, editors) | 1 | 20% |
Mendeley readers
The data shown below were compiled from readership statistics for 1,036 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | <1% |
| Japan | 3 | <1% |
| Chile | 2 | <1% |
| France | 1 | <1% |
| Austria | 1 | <1% |
| Australia | 1 | <1% |
| Brazil | 1 | <1% |
| Germany | 1 | <1% |
| Denmark | 1 | <1% |
| Other | 3 | <1% |
| Unknown | 1019 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 258 | 25% |
| Researcher | 171 | 17% |
| Student > Master | 102 | 10% |
| Student > Bachelor | 102 | 10% |
| Student > Doctoral Student | 74 | 7% |
| Other | 117 | 11% |
| Unknown | 212 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Immunology and Microbiology | 287 | 28% |
| Agricultural and Biological Sciences | 199 | 19% |
| Biochemistry, Genetics and Molecular Biology | 154 | 15% |
| Medicine and Dentistry | 74 | 7% |
| Engineering | 18 | 2% |
| Other | 72 | 7% |
| Unknown | 232 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 18. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 October 2023.
All research outputs
#2,093,243
of 25,837,817 outputs
Outputs from Immunity
#1,514
of 4,864 outputs
Outputs of similar age
#25,967
of 284,421 outputs
Outputs of similar age from Immunity
#23
of 61 outputs
Altmetric has tracked 25,837,817 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,864 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 33.6. This one has gotten more attention than average, scoring higher than 68% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 284,421 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 90% of its contemporaries.
We're also able to compare this research output to 61 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 62% of its contemporaries.