| Title |
Prion-like properties of disease-relevant proteins in amyotrophic lateral sclerosis
|
|---|---|
| Published in |
Journal of Neural Transmission, February 2018
|
| DOI | 10.1007/s00702-018-1851-y |
| Pubmed ID | |
| Authors |
S. Bräuer, V. Zimyanin, A. Hermann |
| Abstract |
The hallmark of age-related neurodegenerative diseases is the appearance of cellular protein deposits and spreading of this pathology throughout the central nervous system. Growing evidence has shown the involvement and critical role of proteins with prion-like properties in the formation of these characteristic cellular aggregates. Prion-like domains of such proteins with their proposed function in the organization of membraneless organelles are prone for misfolding and promoting further aggregation. Spreading of these toxic aggregates between cells and across tissues can explain the progression of clinical phenotypes and pathology in a stereotypical manner, characteristic for almost every neurodegenerative disease. Here, we want to review the current evidence for the role of prion-like mechanisms in classical neurodegenerative diseases and ALS in particular. We will also discuss an intriguingly central role of the protein TDP-43 in the majority of cases of this devastating disease. |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 67 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 67 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 23 | 34% |
| Student > Bachelor | 11 | 16% |
| Researcher | 5 | 7% |
| Student > Doctoral Student | 4 | 6% |
| Student > Master | 4 | 6% |
| Other | 11 | 16% |
| Unknown | 9 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 18 | 27% |
| Neuroscience | 16 | 24% |
| Medicine and Dentistry | 6 | 9% |
| Chemistry | 4 | 6% |
| Engineering | 3 | 4% |
| Other | 10 | 15% |
| Unknown | 10 | 15% |
Attention Score in Context
This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 February 2021.
All research outputs
#2,725,551
of 23,057,470 outputs
Outputs from Journal of Neural Transmission
#128
of 1,784 outputs
Outputs of similar age
#65,778
of 439,557 outputs
Outputs of similar age from Journal of Neural Transmission
#1
of 25 outputs
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