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Development of Salivary Cortisol Circadian Rhythm and Reference Intervals in Full-Term Infants

Overview of attention for article published in PLOS ONE, June 2015
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Title
Development of Salivary Cortisol Circadian Rhythm and Reference Intervals in Full-Term Infants
Published in
PLOS ONE, June 2015
DOI 10.1371/journal.pone.0129502
Pubmed ID
Authors

Katrin Ivars, Nina Nelson, Annette Theodorsson, Elvar Theodorsson, Jakob O. Ström, Evalotte Mörelius

Abstract

Cortisol concentrations in plasma display a circadian rhythm in adults and children older than one year. Earlier studies report divergent results regarding when cortisol circadian rhythm is established. The present study aims to investigate at what age infants develop a circadian rhythm, as well as the possible influences of behavioral regularity and daily life trauma on when the rhythm is established. Furthermore, we determine age-related reference intervals for cortisol concentrations in saliva during the first year of life. 130 healthy full-term infants were included in a prospective, longitudinal study with saliva sampling on two consecutive days, in the morning (07:30-09:30), noon (10:00-12:00) and evening (19:30-21:30), each month from birth until the infant was twelve months old. Information about development of behavioral regularity and potential exposure to trauma was obtained from the parents through the Baby Behavior Questionnaire and the Life Incidence of Traumatic Events checklist. A significant group-level circadian rhythm of salivary cortisol secretion was established at one month, and remained throughout the first year of life, although there was considerable individual variability. No correlation was found between development of cortisol circadian rhythm and the results from either the Baby Behavior Questionnaire or the Life Incidence of Traumatic Events checklist. The study presents salivary cortisol reference intervals for infants during the first twelve months of life. Cortisol circadian rhythm in infants is already established by one month of age, earlier than previous studies have shown. The current study also provides first year age-related reference intervals for salivary cortisol levels in healthy, full-term infants.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 88 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 88 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 16 18%
Student > Ph. D. Student 14 16%
Student > Master 12 14%
Student > Bachelor 7 8%
Student > Doctoral Student 4 5%
Other 18 20%
Unknown 17 19%
Readers by discipline Count As %
Medicine and Dentistry 22 25%
Psychology 11 13%
Nursing and Health Professions 8 9%
Agricultural and Biological Sciences 6 7%
Biochemistry, Genetics and Molecular Biology 4 5%
Other 16 18%
Unknown 21 24%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 October 2017.
All research outputs
#13,746,181
of 22,813,792 outputs
Outputs from PLOS ONE
#111,414
of 194,695 outputs
Outputs of similar age
#128,685
of 264,477 outputs
Outputs of similar age from PLOS ONE
#3,450
of 6,769 outputs
Altmetric has tracked 22,813,792 research outputs across all sources so far. This one is in the 38th percentile – i.e., 38% of other outputs scored the same or lower than it.
So far Altmetric has tracked 194,695 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.1. This one is in the 42nd percentile – i.e., 42% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 264,477 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 50% of its contemporaries.
We're also able to compare this research output to 6,769 others from the same source and published within six weeks on either side of this one. This one is in the 48th percentile – i.e., 48% of its contemporaries scored the same or lower than it.