| Title |
Chronic Melatonin Treatment Prevents Memory Impairment Induced by Chronic Sleep Deprivation
|
|---|---|
| Published in |
Molecular Neurobiology, June 2015
|
| DOI | 10.1007/s12035-015-9286-z |
| Pubmed ID | |
| Authors |
Karem H. Alzoubi, Fadia A. Mayyas, Omar F. Khabour, Fatima M. Bani Salama, Farah H. Alhashimi, Nizar M. Mhaidat |
| Abstract |
Sleep deprivation (SD) has been associated with memory impairment through induction of oxidative stress. Melatonin, which promotes the metabolism of many reactive oxygen species (ROS), has antioxidant and neuroprotective properties. In this study, the effect of melatonin on memory impairment induced by 4 weeks of SD was investigated using rat animal model. Animals were sleep deprived using modified multiple platform model. Melatonin was administered via oral gavage (100 mg/kg/day). Spatial learning and memory were assessed using the radial arm water maze (RAWM). Changes in oxidative stress biomarkers in the hippocampus following treatments were measured using ELISA procedure. The result revealed that SD impaired both short- and long-term memory (P < 0.05). Use of melatonin prevented memory impairment induced by SD. Furthermore, melatonin normalized SD-induced reduction in the hippocampus activity of catalase, glutathione peroxidase (GPx), and superoxide dismutase (SOD). In addition, melatonin enhanced the ratio of reduced to oxidized glutathione GSH/GSSG in sleep-deprived rats (P < 0.05) without affecting thiobarbituric acid reactive substance (TBARS) levels (P > 0.05). In conclusion, SD induced memory impairment, which was prevented by melatonin. This was correlated with normalizing hippocampus antioxidant mechanisms during chronic SD. |
X Demographics
The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Australia | 1 | 20% |
| United States | 1 | 20% |
| United Kingdom | 1 | 20% |
| Finland | 1 | 20% |
| Unknown | 1 | 20% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 5 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 66 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Mexico | 1 | 2% |
| Spain | 1 | 2% |
| Unknown | 64 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 12 | 18% |
| Student > Bachelor | 11 | 17% |
| Researcher | 9 | 14% |
| Student > Master | 8 | 12% |
| Student > Doctoral Student | 3 | 5% |
| Other | 5 | 8% |
| Unknown | 18 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 13 | 20% |
| Biochemistry, Genetics and Molecular Biology | 9 | 14% |
| Medicine and Dentistry | 7 | 11% |
| Psychology | 7 | 11% |
| Agricultural and Biological Sciences | 4 | 6% |
| Other | 7 | 11% |
| Unknown | 19 | 29% |
Attention Score in Context
This research output has an Altmetric Attention Score of 30. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 June 2022.
All research outputs
#1,181,808
of 23,567,572 outputs
Outputs from Molecular Neurobiology
#78
of 3,558 outputs
Outputs of similar age
#15,241
of 265,322 outputs
Outputs of similar age from Molecular Neurobiology
#6
of 135 outputs
Altmetric has tracked 23,567,572 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,558 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.3. This one has done particularly well, scoring higher than 97% of its peers.
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We're also able to compare this research output to 135 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 95% of its contemporaries.