| Title |
The Role of TDP-43 in Alzheimer’s Disease
|
|---|---|
| Published in |
Molecular Neurobiology, June 2015
|
| DOI | 10.1007/s12035-015-9264-5 |
| Pubmed ID | |
| Authors |
Xiao-Long Chang, Meng-Shan Tan, Lan Tan, Jin-Tai Yu |
| Abstract |
The transactive response DNA binding protein (TDP-43) has long been characterized as a main hallmark of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration with ubiquitin-positive inclusions (FTLD-U, also known as FTLD-TDP). Several studies have indicated TDP-43 deposits in Alzheimer's disease (AD) brains and have robust connection with AD clinical phenotype. FTLD-U, which was symptomatically connected with AD, may be predictable for the comprehension of the role TDP-43 in AD. TDP-43 may contribute to AD through both β-amyloid (Aβ)-dependent and Aβ-independent pathways. In this article, we summarize the latest studies concerning the role of TDP-43 in AD and explore TDP-43 modulation as a potential therapeutic strategy for AD. However, to date, little of pieces of the research on TDP-43 have been performed to investigate the role in AD; more investigations need to be confirmed in the future. |
X Demographics
The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 60% |
| Guinea | 1 | 20% |
| Unknown | 1 | 20% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 5 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 124 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 124 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 29 | 23% |
| Researcher | 13 | 10% |
| Student > Bachelor | 12 | 10% |
| Student > Master | 10 | 8% |
| Student > Doctoral Student | 9 | 7% |
| Other | 23 | 19% |
| Unknown | 28 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 23 | 19% |
| Biochemistry, Genetics and Molecular Biology | 22 | 18% |
| Medicine and Dentistry | 17 | 14% |
| Agricultural and Biological Sciences | 16 | 13% |
| Engineering | 4 | 3% |
| Other | 12 | 10% |
| Unknown | 30 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 34. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 September 2021.
All research outputs
#1,043,629
of 23,577,761 outputs
Outputs from Molecular Neurobiology
#69
of 3,562 outputs
Outputs of similar age
#13,329
of 265,766 outputs
Outputs of similar age from Molecular Neurobiology
#5
of 134 outputs
Altmetric has tracked 23,577,761 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,562 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.3. This one has done particularly well, scoring higher than 98% of its peers.
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We're also able to compare this research output to 134 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 96% of its contemporaries.