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Identification of functional endothelial protein C receptor in human plasma.

Overview of attention for article published in Journal of Clinical Investigation, July 1997
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (70th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (58th percentile)

Mentioned by

patent
4 patents

Citations

dimensions_citation
152 Dimensions

Readers on

mendeley
29 Mendeley
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Title
Identification of functional endothelial protein C receptor in human plasma.
Published in
Journal of Clinical Investigation, July 1997
DOI 10.1172/jci119548
Pubmed ID
Authors

S Kurosawa, D J Stearns-Kurosawa, N Hidari, C T Esmon

Abstract

The endothelial cell protein C receptor (EPCR) binds protein C and facilitates activation by the thrombin-thrombomodulin complex. EPCR also binds activated protein C (APC) and inhibits APC anticoagulant activity. In this study, we detected a soluble form of EPCR in normal human plasma. Plasma EPCR appears to be approximately 43, 000 D, and circulates at approximately 100 ng/ml (98.4+/-27.8 ng/ml, n = 22). Plasma EPCR was purified from human citrated plasma using ion exchange, immunoaffinity, and protein C affinity chromatography. Flow cytometry experiments demonstrated that plasma EPCR bound APC with an affinity similar to that previously determined for recombinant soluble EPCR (Kdapp = 30 nM). Furthermore, plasma EPCR inhibited both protein C activation on an endothelial cell line and APC anticoagulant activity in a one-stage Factor Xa clotting assay. The physiological function of plasma EPCR is uncertain, but if the local concentrations are sufficiently high, particularly in disease states, the present data suggest that the soluble plasma EPCR could attenuate the membrane-bound EPCR augmentation of protein C activation and the anticoagulant function of APC.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 29 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 3%
Unknown 28 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 8 28%
Student > Bachelor 3 10%
Student > Master 2 7%
Professor > Associate Professor 2 7%
Professor 2 7%
Other 4 14%
Unknown 8 28%
Readers by discipline Count As %
Medicine and Dentistry 7 24%
Biochemistry, Genetics and Molecular Biology 7 24%
Agricultural and Biological Sciences 6 21%
Veterinary Science and Veterinary Medicine 1 3%
Chemistry 1 3%
Other 0 0%
Unknown 7 24%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 January 2007.
All research outputs
#5,447,195
of 25,374,917 outputs
Outputs from Journal of Clinical Investigation
#6,698
of 17,180 outputs
Outputs of similar age
#4,315
of 28,422 outputs
Outputs of similar age from Journal of Clinical Investigation
#16
of 106 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. Compared to these this one has done well and is in the 75th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 17,180 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 16.7. This one has gotten more attention than average, scoring higher than 50% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 28,422 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.
We're also able to compare this research output to 106 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 58% of its contemporaries.