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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Novel Genes Involved in Controlling Specification of Drosophila FMRFamide Neuropeptide Cells
|
|---|---|
| Published in |
Genetics, June 2015
|
| DOI | 10.1534/genetics.115.178483 |
| Pubmed ID | |
| Authors |
Caroline Bivik, Shahrzad Bahrampour, Carina Ulvklo, Patrik Nilsson, Anna Angel, Fredrik Fransson, Erika Lundin, Jakob Renhorn, Stefan Thor |
| Abstract |
The expression of neuropeptides is often extremely restricted in the nervous system, making them powerful markers for addressing cell specification. In the developing Drosophila ventral nerve cord, only six cells, the Ap4 neurons, out of some 10,000 neurons, express the neuropeptide FMRFamide (FMRFa). Each Ap4/FMRFa neuron is the last-born cell generated by an identifiable and well-studied progenitor cell; neuroblast 5-6 (NB5-6T). The restricted expression of FMRFa and the wealth of information regarding its gene regulation and Ap4 neuron specification, makes FMRFa a valuable readout for addressing many aspects of neural development i.e., spatial and temporal patterning cues, cell cycle control, cell specification, axon transport and retrograde signaling. To this end, we have conducted a forward genetic screen utilizing an Ap4-specific FMRFa-eGFP transgenic reporter as our read-out. A total of 9,781 EMS-mutated chromosomes were screened for perturbations in FMRFa-eGFP expression, and 611 mutants were identified. 79 of the strongest mutants were mapped down to the affected gene, by deficiency mapping or whole-genome sequencing. We isolated novel alleles for previously known FMRFa regulators, confirming the validity of the screen. In addition, we identified novel essential genes, including several with previously undefined functions in neural development. Our identification of genes affecting most major steps required for successful terminal differentiation of Ap4 neurons provides a comprehensive view of the genetic flow controlling the generation of highly unique neuronal cell types in the developing nervous system. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 50% |
| Members of the public | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 37 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 3% |
| Poland | 1 | 3% |
| Canada | 1 | 3% |
| Unknown | 34 | 92% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 8 | 22% |
| Researcher | 7 | 19% |
| Student > Doctoral Student | 6 | 16% |
| Student > Master | 4 | 11% |
| Student > Bachelor | 3 | 8% |
| Other | 5 | 14% |
| Unknown | 4 | 11% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 16 | 43% |
| Biochemistry, Genetics and Molecular Biology | 9 | 24% |
| Neuroscience | 3 | 8% |
| Computer Science | 2 | 5% |
| Nursing and Health Professions | 1 | 3% |
| Other | 2 | 5% |
| Unknown | 4 | 11% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 July 2015.
All research outputs
#16,047,334
of 25,374,647 outputs
Outputs from Genetics
#5,766
of 7,400 outputs
Outputs of similar age
#146,764
of 278,177 outputs
Outputs of similar age from Genetics
#63
of 83 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one is in the 34th percentile – i.e., 34% of other outputs scored the same or lower than it.
So far Altmetric has tracked 7,400 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.6. This one is in the 20th percentile – i.e., 20% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 278,177 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 44th percentile – i.e., 44% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 83 others from the same source and published within six weeks on either side of this one. This one is in the 22nd percentile – i.e., 22% of its contemporaries scored the same or lower than it.