| Title |
The Toxin-Producing Pathobiont Klebsiella oxytoca Is Not Associated with Flares of Inflammatory Bowel Diseases
|
|---|---|
| Published in |
Digestive Diseases and Sciences, June 2015
|
| DOI | 10.1007/s10620-015-3765-y |
| Pubmed ID | |
| Authors |
Ines Zollner-Schwetz, Kathrin A. T. Herzog, Gebhard Feierl, Eva Leitner, Georg Schneditz, Hanna Sprenger, Jürgen Prattes, Wolfgang Petritsch, Heimo Wenzl, Patrizia Kump, Gregor Gorkiewicz, Ellen Zechner, Christoph Högenauer |
| Abstract |
Alterations in the intestinal microbiota are thought to be involved in the pathogenesis of inflammatory bowel diseases (IBD). Klebsiella oxytoca is an intestinal pathobiont that can produce a cytotoxin (tillivaline). We aimed to elucidate the pathogenetic relevance of toxin-producing K. oxytoca in patients with IBD flares and investigated the clonal relationship of K. oxytoca isolates from IBD patients using multilocus sequence typing (MLST). Fecal samples of 235 adult IBD patients were collected from January 2008 to May 2009 and were tested for K. oxytoca, C. difficile toxin, and other pathogens by standard microbiological methods. Clinical data and disease activity scores were collected. K. oxytoca isolates were tested for toxin production using cell culture assays. A total of 45 K. oxytoca isolates from IBD patients, healthy, asymptomatic carriers and from patients with antibiotic-associated hemorrhagic colitis in part from our strain collection were tested for their clonal relationship using MLST. The prevalence of K. oxytoca in IBD overall was 4.7 %. Eleven K. oxytoca isolates were detected. Two of 11 isolates were tested positive for toxin production. There was no significant difference in the distribution of K. oxytoca isolates between the groups (active vs. remission in UC and CD). MLST yielded 33 sequence types. K. oxytoca isolates from IBD did not cluster separately from isolates from asymptomatic carriers. Our data demonstrate that toxin (tilivalline)-producing K. oxytoca is not associated with IBD flares. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 53 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Netherlands | 1 | 2% |
| Unknown | 52 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 8 | 15% |
| Student > Ph. D. Student | 7 | 13% |
| Student > Master | 6 | 11% |
| Researcher | 6 | 11% |
| Other | 3 | 6% |
| Other | 5 | 9% |
| Unknown | 18 | 34% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 12 | 23% |
| Biochemistry, Genetics and Molecular Biology | 6 | 11% |
| Immunology and Microbiology | 5 | 9% |
| Nursing and Health Professions | 3 | 6% |
| Agricultural and Biological Sciences | 2 | 4% |
| Other | 5 | 9% |
| Unknown | 20 | 38% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 June 2015.
All research outputs
#15,631,278
of 23,854,458 outputs
Outputs from Digestive Diseases and Sciences
#2,818
of 4,304 outputs
Outputs of similar age
#148,469
of 267,259 outputs
Outputs of similar age from Digestive Diseases and Sciences
#22
of 66 outputs
Altmetric has tracked 23,854,458 research outputs across all sources so far. This one is in the 32nd percentile – i.e., 32% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,304 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.8. This one is in the 32nd percentile – i.e., 32% of its peers scored the same or lower than it.
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We're also able to compare this research output to 66 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 59% of its contemporaries.