| Title |
Matrix Metalloproteinase-9 Regulates Neuronal Circuit Development and Excitability
|
|---|---|
| Published in |
Molecular Neurobiology, June 2015
|
| DOI | 10.1007/s12035-015-9295-y |
| Pubmed ID | |
| Authors |
Sachiko Murase, Crystal L. Lantz, Eunyoung Kim, Nitin Gupta, Richard Higgins, Mark Stopfer, Dax A. Hoffman, Elizabeth M. Quinlan |
| Abstract |
In early postnatal development, naturally occurring cell death, dendritic outgrowth, and synaptogenesis sculpt neuronal ensembles into functional neuronal circuits. Here, we demonstrate that deletion of the extracellular proteinase matrix metalloproteinase-9 (MMP-9) affects each of these processes, resulting in maladapted neuronal circuitry. MMP-9 deletion increases the number of CA1 pyramidal neurons but decreases dendritic length and complexity. Parallel changes in neuronal morphology are observed in primary visual cortex and persist into adulthood. Individual CA1 neurons in MMP-9(-/-) mice have enhanced input resistance and a significant increase in the frequency, but not amplitude, of miniature excitatory postsynaptic currents (mEPSCs). Additionally, deletion of MMP-9 significantly increases spontaneous neuronal activity in awake MMP-9(-/-) mice and enhances response to acute challenge by the excitotoxin kainate. Our data document a novel role for MMP-9-dependent proteolysis: the regulation of several aspects of circuit maturation to constrain excitability throughout life. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 61 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 3% |
| United Kingdom | 1 | 2% |
| Russia | 1 | 2% |
| Unknown | 57 | 93% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 23 | 38% |
| Researcher | 14 | 23% |
| Professor | 4 | 7% |
| Student > Master | 4 | 7% |
| Student > Bachelor | 3 | 5% |
| Other | 6 | 10% |
| Unknown | 7 | 11% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 19 | 31% |
| Neuroscience | 15 | 25% |
| Biochemistry, Genetics and Molecular Biology | 4 | 7% |
| Psychology | 2 | 3% |
| Medicine and Dentistry | 2 | 3% |
| Other | 6 | 10% |
| Unknown | 13 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 June 2015.
All research outputs
#20,280,315
of 22,813,792 outputs
Outputs from Molecular Neurobiology
#2,788
of 3,453 outputs
Outputs of similar age
#220,123
of 264,243 outputs
Outputs of similar age from Molecular Neurobiology
#109
of 134 outputs
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