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Volume and shape analysis of subcortical brain structures and ventricles in euthymic bipolar I disorder

Overview of attention for article published in Psychiatry Research, May 2015
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Title
Volume and shape analysis of subcortical brain structures and ventricles in euthymic bipolar I disorder
Published in
Psychiatry Research, May 2015
DOI 10.1016/j.pscychresns.2015.05.012
Pubmed ID
Authors

Stephen J. Quigley, Cathy Scanlon, Liam Kilmartin, Louise Emsell, Camilla Langan, Brian Hallahan, Michael Murray, Conor Waters, Mairead Waldron, Sarah Hehir, Helen Casey, Emma McDermott, Jason Ridge, Joanne Kenney, Stefani O’Donoghue, Rory Nannery, Srinath Ambati, Peter McCarthy, Gareth J. Barker, Dara M. Cannon, Colm McDonald

Abstract

Previous structural magnetic resonance imaging (S-MRI) studies of bipolar disorder have reported variable morphological changes in subcortical brain structures and ventricles. This study aimed to establish trait-related subcortical volumetric and shape abnormalities in a large, homogeneous sample of prospectively confirmed euthymic bipolar I disorder (BD-I) patients (n=60), compared with healthy volunteers (n=60). Participants were individually matched for age and gender. Volume and shape metrics were derived from manually segmented S-MR images for the hippocampus, amygdala, caudate nucleus, and lateral ventricles. Group differences were analysed, controlling for age, gender and intracranial volume. BD-I patients displayed significantly smaller left hippocampal volumes and significantly larger left lateral ventricle volumes compared with controls. Shape analysis revealed an area of contraction in the anterior head and medial border of the left hippocampus, as well as expansion in the right hippocampal tail medially, in patients compared with controls. There were no significant associations between volume or shape variation and lithium status or duration of use. A reduction in the head of the left hippocampus in BD-I patients is interesting, given this region's link to verbal memory. Shape analysis of lateral ventricular changes in patients indicated that these are not regionally specific.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 59 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 59 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 10 17%
Student > Ph. D. Student 9 15%
Researcher 7 12%
Student > Doctoral Student 6 10%
Student > Bachelor 4 7%
Other 11 19%
Unknown 12 20%
Readers by discipline Count As %
Psychology 11 19%
Medicine and Dentistry 11 19%
Neuroscience 11 19%
Agricultural and Biological Sciences 5 8%
Nursing and Health Professions 2 3%
Other 4 7%
Unknown 15 25%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 August 2015.
All research outputs
#16,721,717
of 25,374,647 outputs
Outputs from Psychiatry Research
#4,568
of 7,587 outputs
Outputs of similar age
#158,638
of 280,167 outputs
Outputs of similar age from Psychiatry Research
#103
of 214 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one is in the 32nd percentile – i.e., 32% of other outputs scored the same or lower than it.
So far Altmetric has tracked 7,587 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.3. This one is in the 36th percentile – i.e., 36% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 280,167 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 40th percentile – i.e., 40% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 214 others from the same source and published within six weeks on either side of this one. This one is in the 47th percentile – i.e., 47% of its contemporaries scored the same or lower than it.