| Title |
Increased brain-derived neurotrophic factor (BDNF) protein concentrations in mice lacking brain serotonin
|
|---|---|
| Published in |
European Archives of Psychiatry and Clinical Neuroscience, June 2015
|
| DOI | 10.1007/s00406-015-0611-3 |
| Pubmed ID | |
| Authors |
Golo Kronenberg, Valentina Mosienko, Karen Gertz, Natalia Alenina, Rainer Hellweg, Friederike Klempin |
| Abstract |
The interplay between BDNF signaling and the serotonergic system remains incompletely understood. Using a highly sensitive enzyme-linked immunosorbent assay, we studied BDNF concentrations in hippocampus and cortex of two mouse models of altered serotonin signaling: tryptophan hydroxylase (Tph)2-deficient (Tph2 (-/-)) mice lacking brain serotonin and serotonin transporter (SERT)-deficient (SERT(-/-)) mice lacking serotonin re-uptake. Surprisingly, hippocampal BDNF was significantly elevated in Tph2 (-/-) mice, whereas no significant changes were observed in SERT(-/-) mice. Furthermore, BDNF levels were increased in the prefrontal cortex of Tph2 (-/-) but not of SERT(-/-) mice. Our results emphasize the interaction between serotonin signaling and BDNF. Complete lack of brain serotonin induces BDNF expression. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 38 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Brazil | 1 | 3% |
| Unknown | 37 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 10 | 26% |
| Researcher | 6 | 16% |
| Student > Bachelor | 5 | 13% |
| Student > Postgraduate | 3 | 8% |
| Professor > Associate Professor | 2 | 5% |
| Other | 2 | 5% |
| Unknown | 10 | 26% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 11 | 29% |
| Agricultural and Biological Sciences | 5 | 13% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 5% |
| Immunology and Microbiology | 2 | 5% |
| Psychology | 2 | 5% |
| Other | 2 | 5% |
| Unknown | 14 | 37% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 June 2015.
All research outputs
#21,162,249
of 23,815,455 outputs
Outputs from European Archives of Psychiatry and Clinical Neuroscience
#1,094
of 1,243 outputs
Outputs of similar age
#221,937
of 265,286 outputs
Outputs of similar age from European Archives of Psychiatry and Clinical Neuroscience
#13
of 20 outputs
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