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A unique in vivo approach for investigating antimicrobial materials utilizing fistulated animals

Overview of attention for article published in Scientific Reports, June 2015
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1 Facebook page

Citations

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31 Mendeley
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Title
A unique in vivo approach for investigating antimicrobial materials utilizing fistulated animals
Published in
Scientific Reports, June 2015
DOI 10.1038/srep11515
Pubmed ID
Authors

Kyle J. Berean, Eric M. Adetutu, Jian Zhen Ou, Majid Nour, Emily P. Nguyen, David Paull, Jess Mcleod, Rajesh Ramanathan, Vipul Bansal, Kay Latham, Greg J. Bishop-Hurley, Chris McSweeney, Andrew S. Ball, Kourosh Kalantar-zadeh

Abstract

Unique in vivo tests were conducted through the use of a fistulated ruminant, providing an ideal environment with a diverse and vibrant microbial community. Utilizing such a procedure can be especially invaluable for investigating the performance of antimicrobial materials related to human and animal related infections. In this pilot study, it is shown that the rumen of a fistulated animal provides an excellent live laboratory for assessing the properties of antimicrobial materials. We investigate microbial colonization onto model nanocomposites based on silver (Ag) nanoparticles at different concentrations into polydimethylsiloxane (PDMS). With implantable devices posing a major risk for hospital-acquired infections, the present study provides a viable solution to understand microbial colonization with the potential to reduce the incidence of infection through the introduction of Ag nanoparticles at the optimum concentrations. In vitro measurements were also conducted to show the validity of the approach. An optimal loading of 0.25 wt% Ag is found to show the greatest antimicrobial activity and observed through the in vivo tests to reduce the microbial diversity colonizing the surface.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 31 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 3%
Unknown 30 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 6 19%
Student > Master 5 16%
Researcher 5 16%
Student > Doctoral Student 2 6%
Lecturer 2 6%
Other 7 23%
Unknown 4 13%
Readers by discipline Count As %
Agricultural and Biological Sciences 8 26%
Engineering 4 13%
Materials Science 3 10%
Veterinary Science and Veterinary Medicine 2 6%
Chemistry 2 6%
Other 7 23%
Unknown 5 16%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 July 2015.
All research outputs
#20,879,072
of 23,498,099 outputs
Outputs from Scientific Reports
#109,015
of 127,016 outputs
Outputs of similar age
#221,616
of 265,242 outputs
Outputs of similar age from Scientific Reports
#1,696
of 2,035 outputs
Altmetric has tracked 23,498,099 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 127,016 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 18.3. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 265,242 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 2,035 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.