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The p38 mitogen‐activated protein kinase cascade modulates T helper type 17 differentiation and functionality in multiple sclerosis

Overview of attention for article published in Immunology, July 2015
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  • Good Attention Score compared to outputs of the same age (69th percentile)
  • Good Attention Score compared to outputs of the same age and source (71st percentile)

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Title
The p38 mitogen‐activated protein kinase cascade modulates T helper type 17 differentiation and functionality in multiple sclerosis
Published in
Immunology, July 2015
DOI 10.1111/imm.12497
Pubmed ID
Authors

Diletta Di Mitri, Manolo Sambucci, Maria Loiarro, Marco De Bardi, Elisabetta Volpe, Maria Teresa Cencioni, Claudio Gasperini, Diego Centonze, Claudio Sette, Arne N Akbar, Giovanna Borsellino, Luca Battistini

Abstract

The p38 MAPK cascade is required for the induction of a Th17-mediated autoimmune response, which underlies the development and progression of several autoimmune diseases, such as experimental autoimmune encephalomyelitis (EAE), the animal model of multiple sclerosis (MS). However, the contribution of p38 phosphorylation to human Th cell differentiation has not been clarified yet. Here we demonstrate that the p38 signalling pathway is implicated in the generation of Th17 lymphocytes from human CD4(+) CD27(+) CD45RA(+) naive T cells, both in healthy donors and in patients affected by the relapsing remitting form of MS (RR-MS). Our data also indicate that p38 activation is essential for IL-17 release from central memory lymphocytes and committed Th17 cell clones. Furthermore, CD4(+) T cells isolated from RR-MS individuals display an altered responsiveness of the p38 cascade, resulting in increased p38 phosphorylation upon stimulation. These evidences suggest that the p38 signalling pathway, by modulating the Th17 differentiation and response, is involved in the pathogenesis of MS, and open new perspectives for the use of p38 inhibitors in the treatment of Th17-mediated autoimmune diseases. This article is protected by copyright. All rights reserved.

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The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 39 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 39 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 8 21%
Student > Ph. D. Student 5 13%
Student > Master 5 13%
Student > Postgraduate 3 8%
Student > Bachelor 2 5%
Other 7 18%
Unknown 9 23%
Readers by discipline Count As %
Medicine and Dentistry 10 26%
Biochemistry, Genetics and Molecular Biology 4 10%
Agricultural and Biological Sciences 4 10%
Neuroscience 4 10%
Immunology and Microbiology 2 5%
Other 5 13%
Unknown 10 26%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 December 2023.
All research outputs
#7,229,663
of 25,059,640 outputs
Outputs from Immunology
#875
of 2,581 outputs
Outputs of similar age
#77,791
of 267,927 outputs
Outputs of similar age from Immunology
#10
of 32 outputs
Altmetric has tracked 25,059,640 research outputs across all sources so far. This one has received more attention than most of these and is in the 69th percentile.
So far Altmetric has tracked 2,581 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.0. This one has gotten more attention than average, scoring higher than 65% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 267,927 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 69% of its contemporaries.
We're also able to compare this research output to 32 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.