Title |
Selective enhancement of multipotential hematopoietic progenitors in vitro and in vivo by IL-20
|
---|---|
Published in |
Blood, July 2003
|
DOI | 10.1182/blood-2003-05-1419 |
Pubmed ID | |
Authors |
Ling Liu, Chunjin Ding, Wei Zeng, Josef G. Heuer, Jonathan W. Tetreault, Timothy W. Noblitt, Giao Hangoc, Scott Cooper, Kellie A. Brune, Ganesh Sharma, Niles Fox, Scott W. Rowlinson, Danise P. Rogers, Derrick R. Witcher, Peter K. Lambooy, Victor J. Wroblewski, James R. Miller, Hal E. Broxmeyer |
Abstract |
In a search for novel growth factors, we discovered that human interleukin-20 (IL-20) enhanced colony formation by CD34+ multipotential progenitors. IL-20 had no effect on erythroid, granulocyte-macrophage, or megakaryocyte progenitors. IL-20 transgenic mice increased the numbers and cell cycling of multipotential but not other progenitors. IL-20 administration to normal mice significantly increased only multipotential progenitor cells, demonstrating that IL-20 significantly influences hematopoiesis, with specificity toward multipotential progenitors. This is the first cytokine with such specificity identified. |
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