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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Developmental changes in gamma-aminobutyric acid levels in attention-deficit/hyperactivity disorder
|
|---|---|
| Published in |
Translational Psychiatry, June 2015
|
| DOI | 10.1038/tp.2015.79 |
| Pubmed ID | |
| Authors |
S Bollmann, C Ghisleni, S-S Poil, E Martin, J Ball, D Eich-Höchli, R A E Edden, P Klaver, L Michels, D Brandeis, R L O'Gorman |
| Abstract |
While the neurobiological basis and developmental course of attention-deficit/hyperactivity disorder (ADHD) have not yet been fully established, an imbalance between inhibitory/excitatory neurotransmitters is thought to have an important role in the pathophysiology of ADHD. This study examined the changes in cerebral levels of GABA+, glutamate and glutamine in children and adults with ADHD using edited magnetic resonance spectroscopy. We studied 89 participants (16 children with ADHD, 19 control children, 16 adults with ADHD and 38 control adults) in a subcortical voxel (children and adults) and a frontal voxel (adults only). ADHD adults showed increased GABA+ levels relative to controls (P=0.048), while ADHD children showed no difference in GABA+ in the subcortical voxel (P>0.1), resulting in a significant age by disorder interaction (P=0.026). Co-varying for age in an analysis of covariance model resulted in a nonsignificant age by disorder interaction (P=0.06). Glutamine levels were increased in children with ADHD (P=0.041), but there was no significant difference in adults (P>0.1). Glutamate showed no difference between controls and ADHD patients but demonstrated a strong effect of age across both groups (P<0.001). In conclusion, patients with ADHD show altered levels of GABA+ in a subcortical voxel which change with development. Further, we found increased glutamine levels in children with ADHD, but this difference normalized in adults. These observed imbalances in neurotransmitter levels are associated with ADHD symptomatology and lend new insight in the developmental trajectory and pathophysiology of ADHD. |
X Demographics
The data shown below were collected from the profiles of 9 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Canada | 1 | 11% |
| United States | 1 | 11% |
| Unknown | 7 | 78% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 7 | 78% |
| Practitioners (doctors, other healthcare professionals) | 2 | 22% |
Mendeley readers
The data shown below were compiled from readership statistics for 134 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | <1% |
| United States | 1 | <1% |
| Germany | 1 | <1% |
| Canada | 1 | <1% |
| Unknown | 130 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 29 | 22% |
| Student > Master | 18 | 13% |
| Researcher | 16 | 12% |
| Student > Bachelor | 16 | 12% |
| Other | 6 | 4% |
| Other | 22 | 16% |
| Unknown | 27 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 25 | 19% |
| Neuroscience | 20 | 15% |
| Medicine and Dentistry | 16 | 12% |
| Agricultural and Biological Sciences | 12 | 9% |
| Biochemistry, Genetics and Molecular Biology | 7 | 5% |
| Other | 23 | 17% |
| Unknown | 31 | 23% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 May 2023.
All research outputs
#5,879,652
of 24,143,470 outputs
Outputs from Translational Psychiatry
#1,622
of 3,462 outputs
Outputs of similar age
#64,206
of 268,083 outputs
Outputs of similar age from Translational Psychiatry
#21
of 52 outputs
Altmetric has tracked 24,143,470 research outputs across all sources so far. Compared to these this one has done well and is in the 75th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,462 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 23.4. This one has gotten more attention than average, scoring higher than 53% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 268,083 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 76% of its contemporaries.
We're also able to compare this research output to 52 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 61% of its contemporaries.