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Mendeley readers
Attention Score in Context
| Title |
Conservation of polyamine regulation by translational frameshifting from yeast to mammals
|
|---|---|
| Published in |
EMBO Journal, April 2000
|
| DOI | 10.1093/emboj/19.8.1907 |
| Pubmed ID | |
| Authors |
Ivaylo P. Ivanov, Senya Matsufuji, Yasuko Murakami, Raymond F. Gesteland, John F. Atkins |
| Abstract |
Regulation of ornithine decarboxylase in vertebrates involves a negative feedback mechanism requiring the protein antizyme. Here we show that a similar mechanism exists in the fission yeast Schizosaccharomyces pombe. The expression of mammalian antizyme genes requires a specific +1 translational frameshift. The efficiency of the frameshift event reflects cellular polyamine levels creating the autoregulatory feedback loop. As shown here, the yeast antizyme gene and several newly identified antizyme genes from different nematodes also require a ribosomal frameshift event for their expression. Twelve nucleotides around the frameshift site are identical between S.pombe and the mammalian counterparts. The core element for this frameshifting is likely to have been present in the last common ancestor of yeast, nematodes and mammals. |
Mendeley readers
The data shown below were compiled from readership statistics for 63 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 3% |
| Finland | 1 | 2% |
| Germany | 1 | 2% |
| Unknown | 59 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 15 | 24% |
| Student > Ph. D. Student | 14 | 22% |
| Student > Bachelor | 8 | 13% |
| Professor > Associate Professor | 6 | 10% |
| Professor | 4 | 6% |
| Other | 8 | 13% |
| Unknown | 8 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 32 | 51% |
| Biochemistry, Genetics and Molecular Biology | 15 | 24% |
| Immunology and Microbiology | 3 | 5% |
| Medicine and Dentistry | 2 | 3% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 2% |
| Other | 0 | 0% |
| Unknown | 10 | 16% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 December 2006.
All research outputs
#8,543,833
of 25,394,764 outputs
Outputs from EMBO Journal
#6,677
of 12,116 outputs
Outputs of similar age
#13,718
of 40,589 outputs
Outputs of similar age from EMBO Journal
#47
of 96 outputs
Altmetric has tracked 25,394,764 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 12,116 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.7. This one is in the 11th percentile – i.e., 11% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 40,589 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 9th percentile – i.e., 9% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 96 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.