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A genome-wide association study identifies multiple loci for variation in human ear morphology

Overview of attention for article published in Nature Communications, June 2015
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  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (97th percentile)
  • High Attention Score compared to outputs of the same age and source (87th percentile)

Mentioned by

news
3 news outlets
twitter
73 X users
facebook
1 Facebook page
reddit
2 Redditors

Citations

dimensions_citation
77 Dimensions

Readers on

mendeley
147 Mendeley
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1 CiteULike
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Title
A genome-wide association study identifies multiple loci for variation in human ear morphology
Published in
Nature Communications, June 2015
DOI 10.1038/ncomms8500
Pubmed ID
Authors

Kaustubh Adhikari, Guillermo Reales, Andrew J. P. Smith, Esra Konka, Jutta Palmen, Mirsha Quinto-Sanchez, Victor Acuña-Alonzo, Claudia Jaramillo, William Arias, Macarena Fuentes, María Pizarro, Rodrigo Barquera Lozano, Gastón Macín Pérez, Jorge Gómez-Valdés, Hugo Villamil-Ramírez, Tábita Hunemeier, Virginia Ramallo, Caio C. Silva de Cerqueira, Malena Hurtado, Valeria Villegas, Vanessa Granja, Carla Gallo, Giovanni Poletti, Lavinia Schuler-Faccini, Francisco M. Salzano, Maria- Cátira Bortolini, Samuel Canizales-Quinteros, Francisco Rothhammer, Gabriel Bedoya, Rosario Calderón, Javier Rosique, Michael Cheeseman, Mahmood F. Bhutta, Steve E. Humphries, Rolando Gonzalez-José, Denis Headon, David Balding, Andrés Ruiz-Linares

Abstract

Here we report a genome-wide association study for non-pathological pinna morphology in over 5,000 Latin Americans. We find genome-wide significant association at seven genomic regions affecting: lobe size and attachment, folding of antihelix, helix rolling, ear protrusion and antitragus size (linear regression P values 2 × 10(-8) to 3 × 10(-14)). Four traits are associated with a functional variant in the Ectodysplasin A receptor (EDAR) gene, a key regulator of embryonic skin appendage development. We confirm expression of Edar in the developing mouse ear and that Edar-deficient mice have an abnormally shaped pinna. Two traits are associated with SNPs in a region overlapping the T-Box Protein 15 (TBX15) gene, a major determinant of mouse skeletal development. Strongest association in this region is observed for SNP rs17023457 located in an evolutionarily conserved binding site for the transcription factor Cartilage paired-class homeoprotein 1 (CART1), and we confirm that rs17023457 alters in vitro binding of CART1.

X Demographics

X Demographics

The data shown below were collected from the profiles of 73 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 147 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 1 <1%
Australia 1 <1%
Brazil 1 <1%
United Kingdom 1 <1%
Mexico 1 <1%
Argentina 1 <1%
Unknown 141 96%

Demographic breakdown

Readers by professional status Count As %
Researcher 24 16%
Student > Ph. D. Student 22 15%
Student > Master 19 13%
Student > Bachelor 15 10%
Professor 8 5%
Other 32 22%
Unknown 27 18%
Readers by discipline Count As %
Agricultural and Biological Sciences 41 28%
Biochemistry, Genetics and Molecular Biology 28 19%
Medicine and Dentistry 19 13%
Arts and Humanities 6 4%
Nursing and Health Professions 4 3%
Other 19 13%
Unknown 30 20%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 68. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 January 2022.
All research outputs
#631,547
of 25,562,515 outputs
Outputs from Nature Communications
#10,916
of 57,632 outputs
Outputs of similar age
#6,963
of 278,719 outputs
Outputs of similar age from Nature Communications
#106
of 811 outputs
Altmetric has tracked 25,562,515 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 57,632 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 55.5. This one has done well, scoring higher than 81% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 278,719 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 811 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 87% of its contemporaries.