Title |
Identification of a novel homozygous UNC80 variant in a child with infantile hypotonia with psychomotor retardation and characteristic facies-2 (IHPRF2)
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Published in |
Metabolic Brain Disease, February 2018
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DOI | 10.1007/s11011-018-0200-z |
Pubmed ID | |
Authors |
Tasneem Obeid, Abdul Rezzak Hamzeh, Fatima Saif, Pratibha Nair, Madiha Mohamed, Mahmoud Taleb Al-Ali, Fatma Bastaki |
Abstract |
The UNC80 gene encodes for a large component of the NALCN sodium-leak channel complex that regulates the basal excitability of the nervous system. In this study, we report on a novel homozygous mutation in UNC80 in a Palestinian-Emirati patient suffering infantile hypotonia with psychomotor retardation and characteristic facies. This mutation was detected by whole exome sequencing and confirmed using Sanger sequencing in the patient-parents trio. Numerous elements in the patient's phenotype were in agreement with the few reported cases of UNC80 mutations; however there are some notable differences. We present comprehensive clinical and molecular accounts of this mutation in addition to a full review of previously reported patients of UNC80 mutations. |
X Demographics
Geographical breakdown
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United Arab Emirates | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 15 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 4 | 27% |
Student > Bachelor | 2 | 13% |
Librarian | 1 | 7% |
Other | 1 | 7% |
Student > Master | 1 | 7% |
Other | 1 | 7% |
Unknown | 5 | 33% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 4 | 27% |
Agricultural and Biological Sciences | 2 | 13% |
Neuroscience | 2 | 13% |
Psychology | 1 | 7% |
Unknown | 6 | 40% |