| Title |
Telomeres and Telomerase During Human Papillomavirus-Induced Carcinogenesis
|
|---|---|
| Published in |
Molecular Diagnosis & Therapy, May 2018
|
| DOI | 10.1007/s40291-018-0336-x |
| Pubmed ID | |
| Authors |
Anna Pańczyszyn, Ewa Boniewska-Bernacka, Grzegorz Głąb |
| Abstract |
Human papillomaviruses (HPVs) belong to a small spherical virus family and are transmitted through direct contact, most often through sexual behavior. More than 200 types of HPV are known, a dozen or so of which are classified as high-risk viruses (HR HPV) and may contribute to the development of cervical cancer. HPV is a small virus with a capsid composed of L1 and L2 proteins, which are crucial for entry to the cell. The infection begins at the basal cell layer and progresses to involve cells from higher layers of the cervical epithelium. E6 and E7 viral proteins are involved in the process of carcinogenesis. They interact with suppressors of oncogenesis, including p53 and Rb proteins. This leads to DNA replication and intensive cell divisions. The persistent HR HPV infection leads to the development of dysplasia and these changes may progress to invasive cancer. During the initial stage of carcinogenesis, telomeres shorten until telomerase activates. The activation of telomerase, the enzyme necessary to extend chromosome ends (telomeres) is the key step in cell immortalization. Analyzing the expression level of hTERT and hTERC genes encoding telomerase and telomere length measurement may constitute new markers of the early carcinogenesis. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 72 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 72 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 14 | 19% |
| Student > Bachelor | 10 | 14% |
| Student > Ph. D. Student | 7 | 10% |
| Student > Doctoral Student | 6 | 8% |
| Researcher | 3 | 4% |
| Other | 8 | 11% |
| Unknown | 24 | 33% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 18 | 25% |
| Medicine and Dentistry | 11 | 15% |
| Agricultural and Biological Sciences | 5 | 7% |
| Immunology and Microbiology | 3 | 4% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 4% |
| Other | 6 | 8% |
| Unknown | 26 | 36% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 May 2018.
All research outputs
#18,616,612
of 23,061,402 outputs
Outputs from Molecular Diagnosis & Therapy
#272
of 386 outputs
Outputs of similar age
#254,429
of 329,133 outputs
Outputs of similar age from Molecular Diagnosis & Therapy
#8
of 11 outputs
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