| Title |
Increasing signal intensity within the dentate nucleus and globus pallidus on unenhanced T1W magnetic resonance images in patients with relapsing-remitting multiple sclerosis: correlation with cumulative dose of a macrocyclic gadolinium-based contrast agent, gadobutrol
|
|---|---|
| Published in |
European Radiology, June 2015
|
| DOI | 10.1007/s00330-015-3879-9 |
| Pubmed ID | |
| Authors |
Dragan A. Stojanov, Aleksandra Aracki-Trenkic, Slobodan Vojinovic, Daniela Benedeto-Stojanov, Srdjan Ljubisavljevic |
| Abstract |
To evaluate correlation between cumulative dose of gadobutrol and signal intensity (SI) within dentate nucleus and globus pallidus on unenhanced T1-weighted images in patients with relapsing-remitting multiple sclerosis (RRMS). Dentate nucleus-to-pons and globus pallidus-to-thalamus SI ratios, and renal and liver functions, were evaluated after multiple intravenous administrations of 0.1 mmol/kg gadobutrol at 27, 96-98, and 168 weeks. We compared SI ratios based on the number of administrations, total amount of gadobutrol administered, and time between injections. Globus pallidus-to-thalamus (p = 0.025) and dentate nucleus-to-pons (p < 0.001) SI ratios increased after multiple gadobutrol administrations, correlated with the number of administrations (ρ = 0.263, p = 0.046, respectively) and depended on the length of administration (p = 0.017, p = 0.037, respectively). Patients receiving gadobutrol at 27 weeks showed the greatest increase in both SI ratios (p = 0.006; p = 0.014, respectively, versus 96-98 weeks). GGT increased at the end of the study (p = 0.004). In patients with RRMS, SI within the dentate nucleus and globus pallidus increased on unenhanced T1-weighted images after multiple gadobutrol injections. Administration of the same total amount of gadobutrol over a shorter period caused greater SI increase. • Gadolinium deposition may occur within the human brain after multiple gadolinium contrast administrations • Increasing T1W signal intensity occurs within the dentate nucleus and globus pallidus • Increasing signal intensity may be a consequence of multiple administrations of gadobutrol • Administration of gadobutrol over a shorter period causes greater signal intensity increase. |
X Demographics
The data shown below were collected from the profiles of 7 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | 14% |
| Austria | 1 | 14% |
| Unknown | 5 | 71% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 5 | 71% |
| Science communicators (journalists, bloggers, editors) | 2 | 29% |
Mendeley readers
The data shown below were compiled from readership statistics for 153 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Norway | 1 | <1% |
| Unknown | 152 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 29 | 19% |
| Other | 27 | 18% |
| Student > Bachelor | 18 | 12% |
| Student > Ph. D. Student | 16 | 10% |
| Student > Master | 12 | 8% |
| Other | 31 | 20% |
| Unknown | 20 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 79 | 52% |
| Neuroscience | 13 | 8% |
| Chemistry | 11 | 7% |
| Agricultural and Biological Sciences | 4 | 3% |
| Biochemistry, Genetics and Molecular Biology | 4 | 3% |
| Other | 14 | 9% |
| Unknown | 28 | 18% |
Attention Score in Context
This research output has an Altmetric Attention Score of 15. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 November 2022.
All research outputs
#2,388,245
of 25,137,221 outputs
Outputs from European Radiology
#202
of 4,872 outputs
Outputs of similar age
#29,244
of 269,600 outputs
Outputs of similar age from European Radiology
#3
of 57 outputs
Altmetric has tracked 25,137,221 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,872 research outputs from this source. They receive a mean Attention Score of 4.6. This one has done particularly well, scoring higher than 95% of its peers.
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We're also able to compare this research output to 57 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 96% of its contemporaries.