Title |
High incidence of primary melanomas in an MC1R RHC homozygote/CDKN2A mutant genotype patient
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Published in |
Archives of Dermatological Research, June 2015
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DOI | 10.1007/s00403-015-1582-y |
Pubmed ID | |
Authors |
Sudipta Sinnya, Kasturee Jagirdar, Brian De’Ambrosis, Erin McMeniman, Richard A. Sturm, H. Peter Soyer |
Abstract |
Melanoma incidence in Australia remains the highest in the world; hence understanding its causation is paramount for future therapeutic developments. Multiple primary melanomas are also common occurrences among the Australian population with identified risk factors such as personal and family history of melanoma, fair skin type, dysplastic naevus syndrome and history of significant ultraviolet exposure. The roles of both environmental and genetic factors have been elucidated in melanoma development, but the synergy of interactions between the two remains complex given the heterogeneous nature of the disease. We present a rare case of a 57-year-old female with 20 cutaneous melanomas and review the role of genetic and environmental factors in development of her multiple primary melanomas. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Australia | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 6 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 2 | 33% |
Professor | 1 | 17% |
Professor > Associate Professor | 1 | 17% |
Other | 1 | 17% |
Unknown | 1 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 3 | 50% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 17% |
Unknown | 2 | 33% |