↓ Skip to main content

YB-1 Relocates to the Nucleus in Adenovirus-infected Cells and Facilitates Viral Replication by Inducing E2 Gene Expression through the E2 Late Promoter*

Overview of attention for article published in Journal of Biological Chemistry, January 2002
Altmetric Badge

About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (91st percentile)
  • High Attention Score compared to outputs of the same age and source (86th percentile)

Mentioned by

patent
13 patents

Citations

dimensions_citation
92 Dimensions

Readers on

mendeley
59 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
YB-1 Relocates to the Nucleus in Adenovirus-infected Cells and Facilitates Viral Replication by Inducing E2 Gene Expression through the E2 Late Promoter*
Published in
Journal of Biological Chemistry, January 2002
DOI 10.1074/jbc.m106955200
Pubmed ID
Authors

Per S. Holm, Stephan Bergmann, Karsten Jürchott, Hermann Lage, Karsten Brand, Axel Ladhoff, Klaus Mantwill, David T. Curiel, Matthias Dobbelstein, Manfred Dietel, Bernd Gänsbacher, Hans-Dieter Royer

Abstract

The adenovirus early proteins E1A and E1B-55kDa are key regulators of viral DNA replication, and it was thought that targeting of p53 by E1B-55kDa is essential for this process. Here we have identified a previously unrecognized function of E1B for adenovirus replication. We found that E1B-55kDa is involved in targeting the transcription factor YB-1 to the nuclei of adenovirus type 5-infected cells where it is associated with viral inclusion bodies believed to be sites of viral transcription and replication. We show that YB-1 facilitates E2 gene expression through the E2 late promoter thus controlling E2 gene activity at later stages of infection. The role of YB-1 for adenovirus replication was demonstrated with an E1-minus adenovirus vector containing a YB-1 transgene. In infected cells, AdYB-1 efficiently replicated and produced infectious progeny particles. Thus, adenovirus E1B-55kDa protein and the host cell factor YB-1 act jointly to facilitate adenovirus replication in the late phase of infection.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 59 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 2%
Unknown 58 98%

Demographic breakdown

Readers by professional status Count As %
Researcher 15 25%
Student > Ph. D. Student 10 17%
Student > Master 9 15%
Student > Bachelor 7 12%
Student > Doctoral Student 2 3%
Other 7 12%
Unknown 9 15%
Readers by discipline Count As %
Agricultural and Biological Sciences 22 37%
Biochemistry, Genetics and Molecular Biology 19 32%
Medicine and Dentistry 4 7%
Linguistics 1 2%
Immunology and Microbiology 1 2%
Other 3 5%
Unknown 9 15%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 June 2022.
All research outputs
#3,798,287
of 25,371,288 outputs
Outputs from Journal of Biological Chemistry
#6,156
of 85,238 outputs
Outputs of similar age
#8,589
of 131,125 outputs
Outputs of similar age from Journal of Biological Chemistry
#49
of 887 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. Compared to these this one has done well and is in the 83rd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 85,238 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.1. This one has done well, scoring higher than 86% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 131,125 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 91% of its contemporaries.
We're also able to compare this research output to 887 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 86% of its contemporaries.