Title |
Is Neonatal Jaundice Associated with Autism Spectrum Disorders: A Systematic Review
|
---|---|
Published in |
Journal of Autism and Developmental Disorders, March 2011
|
DOI | 10.1007/s10803-010-1169-6 |
Pubmed ID | |
Authors |
Sanjiv B. Amin, Tristram Smith, Hongyue Wang |
Abstract |
Using guidelines of the Meta-analysis of Observational Studies in Epidemiology Group, we systematically reviewed the literature on neonatal jaundice (unconjugated hyperbilirubinemia) and Autism Spectrum Disorder (ASD) in term and preterm infants. Thirteen studies were included in a meta-analysis. Most used retrospective matched case-control designs. There was significant heterogeneity (Q = 31, p = 0.002) and no evidence of publication bias (p = 0.12). Overall, jaundice, assessed by total serum bilirubin (TSB), was associated with ASD (OR, 1.43, 95% CI 1.22-1.67, random effect model). This association was not found in preterms (OR 0.7, 95% CI 0.38-1.02) but deserves further investigation since other measures of bilirubin such as unbound unconjugated bilirubin may be better predictors of neurotoxicity than TSB in preterms. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 2 | 29% |
Unknown | 5 | 71% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 7 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 2% |
South Africa | 1 | <1% |
Unknown | 118 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 21 | 17% |
Student > Master | 16 | 13% |
Student > Bachelor | 13 | 11% |
Student > Ph. D. Student | 11 | 9% |
Student > Doctoral Student | 10 | 8% |
Other | 30 | 25% |
Unknown | 20 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 32 | 26% |
Psychology | 20 | 17% |
Nursing and Health Professions | 11 | 9% |
Biochemistry, Genetics and Molecular Biology | 7 | 6% |
Social Sciences | 6 | 5% |
Other | 20 | 17% |
Unknown | 25 | 21% |