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The MRN complex: coordinating and mediating the response to broken chromosomes

Overview of attention for article published in EMBO Reports, September 2003
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (71st percentile)
  • Above-average Attention Score compared to outputs of the same age and source (56th percentile)

Mentioned by

patent
3 patents

Citations

dimensions_citation
214 Dimensions

Readers on

mendeley
205 Mendeley
citeulike
1 CiteULike
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Title
The MRN complex: coordinating and mediating the response to broken chromosomes
Published in
EMBO Reports, September 2003
DOI 10.1038/sj.embor.embor925
Pubmed ID
Authors

Michael van den Bosch, Ronan T Bree, Noel F Lowndes

Abstract

The MRE11-RAD50-NBS1 (MRN) protein complex has been linked to many DNA metabolic events that involve DNA double-stranded breaks (DSBs). In vertebrate cells, all three components are encoded by essential genes, and hypomorphic mutations in any of the human genes can result in genome-instability syndromes. MRN is one of the first factors to be localized to the DNA lesion, where it might initially have a structural role by tethering together, and therefore stabilizing, broken chromosomes. This suggests that MRN could function as a lesion-specific sensor. As well as binding to DNA, MRN has other roles in both the processing and assembly of large macromolecular complexes (known as foci) that facilitate efficient DSB responses. Recently, a novel mediator protein, mediator of DNA damage checkpoint protein 1 (MDC1), was shown to co-immunoprecipitate with the MRN complex and regulate MRE11 foci formation. However, whether the initial recruitment of MRN to DSBs requires MDC1 is unclear. Here, we focus on recent developments in MRN research and propose a model for how DSBs are sensed and the cellular responses to them are mediated.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 205 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 2 <1%
Brazil 2 <1%
Germany 1 <1%
Bulgaria 1 <1%
Netherlands 1 <1%
Cyprus 1 <1%
United Kingdom 1 <1%
Czechia 1 <1%
China 1 <1%
Other 1 <1%
Unknown 193 94%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 61 30%
Student > Master 35 17%
Researcher 31 15%
Student > Bachelor 19 9%
Student > Doctoral Student 9 4%
Other 29 14%
Unknown 21 10%
Readers by discipline Count As %
Agricultural and Biological Sciences 89 43%
Biochemistry, Genetics and Molecular Biology 65 32%
Medicine and Dentistry 13 6%
Chemistry 3 1%
Immunology and Microbiology 2 <1%
Other 10 5%
Unknown 23 11%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 March 2011.
All research outputs
#4,767,124
of 23,061,402 outputs
Outputs from EMBO Reports
#1,454
of 3,710 outputs
Outputs of similar age
#8,512
of 50,211 outputs
Outputs of similar age from EMBO Reports
#9
of 30 outputs
Altmetric has tracked 23,061,402 research outputs across all sources so far. Compared to these this one has done well and is in the 76th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,710 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 13.0. This one has gotten more attention than average, scoring higher than 56% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 50,211 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.
We're also able to compare this research output to 30 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 56% of its contemporaries.