| Title |
Neonatal Diabetes: An Expanding List of Genes Allows for Improved Diagnosis and Treatment
|
|---|---|
| Published in |
Current Diabetes Reports, October 2011
|
| DOI | 10.1007/s11892-011-0234-7 |
| Pubmed ID | |
| Authors |
Siri Atma W. Greeley, Rochelle N. Naylor, Louis H. Philipson, Graeme I. Bell |
| Abstract |
There has been major progress in recent years uncovering the genetic causes of diabetes presenting in the first year of life. Twenty genes have been identified to date. The most common causes accounting for the majority of cases are mutations in the genes encoding the two subunits of the ATP-sensitive potassium channel (K(ATP)), KCNJ11 and ABCC8, and the insulin gene (INS), as well as abnormalities in chromosome 6q24. Patients with activating mutations in KCNJ11 and ABCC8 can be treated with oral sulfonylureas in lieu of insulin injections. This compelling example of personalized genetic medicine leading to improved glucose regulation and quality of life may-with continued research-be repeated for other forms of neonatal diabetes in the future. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Practitioners (doctors, other healthcare professionals) | 1 | 50% |
| Members of the public | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 110 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Chile | 1 | <1% |
| Unknown | 109 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 19 | 17% |
| Student > Ph. D. Student | 16 | 15% |
| Student > Doctoral Student | 12 | 11% |
| Student > Bachelor | 11 | 10% |
| Researcher | 9 | 8% |
| Other | 27 | 25% |
| Unknown | 16 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 34 | 31% |
| Biochemistry, Genetics and Molecular Biology | 22 | 20% |
| Agricultural and Biological Sciences | 13 | 12% |
| Nursing and Health Professions | 7 | 6% |
| Immunology and Microbiology | 3 | 3% |
| Other | 10 | 9% |
| Unknown | 21 | 19% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 May 2015.
All research outputs
#13,356,164
of 22,655,397 outputs
Outputs from Current Diabetes Reports
#539
of 1,005 outputs
Outputs of similar age
#84,789
of 135,903 outputs
Outputs of similar age from Current Diabetes Reports
#4
of 6 outputs
Altmetric has tracked 22,655,397 research outputs across all sources so far. This one is in the 39th percentile – i.e., 39% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,005 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.0. This one is in the 44th percentile – i.e., 44% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 135,903 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 35th percentile – i.e., 35% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 6 others from the same source and published within six weeks on either side of this one. This one has scored higher than 2 of them.