| Title |
Multifaceted roles of HSF1 in cancer
|
|---|---|
| Published in |
Tumor Biology, June 2015
|
| DOI | 10.1007/s13277-015-3674-x |
| Pubmed ID | |
| Authors |
Sufang Jiang, Kailing Tu, Qiang Fu, David C. Schmitt, Lan Zhou, Na Lu, Yuhua Zhao |
| Abstract |
Heat shock transcription factor 1 (HSF1) is the master regulator of the heat shock response. Accumulating evidence shows that HSF1 is overexpressed in a variety of human cancers, is associated with cancer aggressiveness, and could serve as an independent diagnostic or prognostic biomarker. In this review, we will provide an overview of the multifaceted roles of HSF1 in cancer, with a special focus on the four underlying molecular mechanisms involved. First, HSF1 regulates the expression of heat shock proteins (HSPs) including HSP90, HSP70, and HSP27. Second, HSF1 regulates cellular metabolism, including glycolysis and lipid metabolism. Third, HSF1 serves as a regulator of different signaling pathways, such as HuR-HIF-1, Slug, protein kinase C (PKC), nuclear factor-kappaB (NF-κB), PI3K-AKT-mTOR, and mitogen-activated protein kinase (MAPK) pathways. Finally, HSF1 regulates microRNAs (miRNAs) and long non-coding RNAs (lncRNAs). Overall, HSF1 plays many important roles in cancer via regulating cell proliferation, anti-apoptosis, epithelial-mesenchymal transition (EMT), migration, invasion, and metastasis and may be a potential therapeutic target for human cancers. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 79 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 79 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 16 | 20% |
| Student > Ph. D. Student | 14 | 18% |
| Student > Master | 11 | 14% |
| Researcher | 8 | 10% |
| Student > Doctoral Student | 4 | 5% |
| Other | 14 | 18% |
| Unknown | 12 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 23 | 29% |
| Biochemistry, Genetics and Molecular Biology | 20 | 25% |
| Medicine and Dentistry | 13 | 16% |
| Immunology and Microbiology | 3 | 4% |
| Veterinary Science and Veterinary Medicine | 2 | 3% |
| Other | 4 | 5% |
| Unknown | 14 | 18% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 June 2015.
All research outputs
#18,417,643
of 22,815,414 outputs
Outputs from Tumor Biology
#1,369
of 2,622 outputs
Outputs of similar age
#189,533
of 263,898 outputs
Outputs of similar age from Tumor Biology
#71
of 164 outputs
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