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Inhibition of natural killer cell activity of human lymphocytes by eicosapentaenoic acid

Overview of attention for article published in Biochemical & Biophysical Research Communications, August 1986
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Title
Inhibition of natural killer cell activity of human lymphocytes by eicosapentaenoic acid
Published in
Biochemical & Biophysical Research Communications, August 1986
DOI 10.1016/s0006-291x(86)80389-8
Pubmed ID
Authors

Naohiro Yamashita, Akihito Yokoyama, Tomohito Hamazaki, Saburo Yano

Abstract

The effect of eicosapentaenoic acid (EPA) on natural killer (NK) cell activity of human lymphocytes was examined. The addition of an emulsion of trieicosapentaenoyl-glycerol (EPA-TG) emulsified with purified phosphatidylcholine from krill to a cytotoxicity assay system resulted in a marked depression of NK activity. The inhibition was proportional to the concentration of EPA-TG emulsion, and was observed as early as the first one hour of incubation at various effector to target cell ratios. Pretreatment of effector cells with EPA-TG emulsion resulted in significant suppression of their NK activity. Inhibition of cytotoxicity was not due to direct toxicity to effector cells or decreased target cell binding. These results indicate that EPA is a potent inhibitor of NK activity in vitro.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 4 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 4 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 1 25%
Lecturer 1 25%
Student > Master 1 25%
Unknown 1 25%
Readers by discipline Count As %
Neuroscience 1 25%
Medicine and Dentistry 1 25%
Unknown 2 50%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 August 2023.
All research outputs
#8,535,684
of 25,374,917 outputs
Outputs from Biochemical & Biophysical Research Communications
#7,621
of 26,637 outputs
Outputs of similar age
#3,012
of 10,377 outputs
Outputs of similar age from Biochemical & Biophysical Research Communications
#18
of 63 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 26,637 research outputs from this source. They receive a mean Attention Score of 4.5. This one is in the 28th percentile – i.e., 28% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 10,377 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 8th percentile – i.e., 8% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 63 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.